Drug Discovery - Target to Lead

Drug-development projects consider both scientific and commercial factors:

Yes. (#1 step- Project initiation.)

What are the 4 Drug development factors

Unmet medical needs/ therapeutic opportunity

Unmet medical needs/ therapeutic opportunity

Technical + scientific Feasibility (Achievable)

Cost + risk of development

Commercial Potential

After drug development, what happens in Project Initiation?

Initial Assessment

What happens in initial assessment?

Market Analysis

Competitive Assessment

Research Analysis

What’s Step 2? What are the main points?

Market Analysis

• - Size of the potential patient population

• - Disease characteristics

- Existing treatment

- Access and Reimbursement options

What do you check for in (#2) during Existing Treatments?

Drugs

• Effectiveness of of it

• Safety

• Cost

• Convenience

What are the 2 Disease Characteristics

Severity + unmet medical need

Short term (Acute) vs Long term (chronic) medical need

Are cancer drugs the most profited and produced?

Yes

Whats Step #3

Competitive Assessment

Competitive assessment does what? What are they developing? What does Timing market entry mean? What happens to later Entrants

Competitive in marketing drugs.

If properly Tim[ed] for market entry

- “First-to-market may provide an advantage”

Later entrants succeed if they offer me meaningful improvements

Is potential differentiation part of competitive Assessment (#3)

Yes

What does Potential differentiaqtion do?

Help with

• - Greater Efficacy

• - Improved safety

• - Low cost—-. Better access

• - Convenient Dossing/ Administration

• - Better Patient Adherence (Patient is able to stick to medical plans better—> Less frequent consumption/ better timings)

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