Chapter 13 Study Guide: Blood Clotting Factors

Vocabulary flashcards covering the names, sources, pathways, and characteristics of the 12 active blood clotting factors as presented in Chapter 13 of Human Physiology BIO 261.

Factor $I$ (Fibrinogen)

A plasma protein source from the liver; acts in the common pathway and is converted into fibrin.

Factor $II$ (Prothrombin)

A plasma protein sourced from the liver; acts in the common pathway and is converted into thrombin.

Factor $III$ (Tissue thromboplastin or tissue factor)

A lipoprotein mixture from damaged cells and platelets; acts in the extrinsic pathway.

Factor $IV$ (Calcium ions)

Inorganic ions from the diet, platelets, and bone matrix; involved in the entire clotting process.

Factor $V$ (Proaccelerin)

A plasma protein source from the liver and platelets; involved in both extrinsic and intrinsic pathways.

Factor $VII$ (Proconvertin)

A plasma protein source from the liver; involved in the extrinsic pathway.

Factor $VIII$ (Antihemolytic factor A)

A platelet and endothelial cell protein factor; involved in the intrinsic pathway, deficiency results in hemophilia A.

Factor $IX$ (Antihemolytic factor B)

Also known as plasma thromboplastin component; a plasma protein from the liver; involved in the intrinsic pathway, deficiency results in hemophilia B.

Factor $X$ (Stuart-Prower factor)

Also known as thrombokinase; a protein from the liver; involved in both extrinsic and intrinsic pathways.

Factor $XI$ (Antihemolytic factor C)

Also known as plasma thromboplastin antecedent; a plasma protein from the liver; involved in the intrinsic pathway, deficiency results in hemophilia C.

Factor $XII$ (Hageman factor)

A plasma protein from the liver; involved in the intrinsic pathway; initiates clotting in vitro and also activates plasmin.

Factor $XIII$ (Fibrin-stabilizing factor)

A plasma protein from the liver and platelets; stabilizes fibrin and slows fibrinolysis.