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Potassium (K+)dominates salt in
Intracellular Fluids (ICF)
Sodium (Na+) dominates salt in
Extracellular (ECF)
Active Transport requires
ATP
Water balance changes are detected in the
hypothalamus
When detecting water balance changes(dehydration) the hypothalamus…
activates sensation of thirst
produces Antiduretic hormone (ADH) which causes the kidneys to retain fluids and reduce urine production
Osmoregulation
regulation of water content in blood
Excretion
Filter solutes out blood, then use cellular transport mechanisms to regulate what stays in the urine and what should return to the blood.
Each kidney is made of 1.25 million…
nephrons
Glomerulus
filters various substances from the blood, has fenestrations (small slits) that open under high blood pressure.
Bowman’s Capsule
filters blood and collects the resulting filtrate to begin urine formation
acts as a cup-shaped structure that surrounds the glomerulus
Ascending Limb of the loop of Henle
Na+, K+, and 2 Cl- reabsorber into cells or bloodstream
Proximal Conviluted tubule
Selective reabsorption of Sugars, amino acids, and Na+ into cells or bloodstream
What structures are in the Outer Medulla?
Descending limb of LOH, Loop of Henle, Acending limb of LOH, Collecting duct
What structures are in the Cortex?
Glomerulus, Proximal convoluted tubule, Distal convoluted tubule
Distal convoluted tubule
see image
What structures ultrafiltrates
Bowman’s Capsule
What structures selective reabsorb
Proximal Tubule, Distal Tubule
What structures osmoregulate?
Loop of Henle(salt gradient), collecting duct(water retention)
Each nephron contains a very small branch of the renal artery known as an afferent arteriole.
This very small artery brings unfiltered blood to the nephron.
Inside the Bowman's capsule, the afferent arteriole branches into a specialized capillary bed called the glomerulus.
efferent arteriole
drains blood from the glomerulus & has a smaller diameter than the afferent arteriole.
Ultrafiltration
the process by which various substances are filtered through the glomerulus (& its fenestrations) under high blood pressure in the capillary bed.
portal system of circulation
a series of veins that connect two capillary beds, allowing blood to flow from one set of capillaries to another before returning to the heart
Microvilli
microscopic projections found only in the plasma membrane portion facing the lumen of the tubule.
Lumen
the hollow space or cavity inside a tubular structure, such as a blood vessel, intestine, or organelle
Uric acid
a complex & energy- requiring molecule to produce but it is not toxic to living tissues bc it is insoluble in body fluids.
Urea
the molecule produced by organisms that have to make a compromise between toxicity & the need for temporary storage of a waste product (such as urine in mammals).
Desending Loop of Henle
permeable to water but relatively impermeable to mineral ions.
Permeable
allowing liquids or gases to pass through it
Impermeable
NOT allowing liquids or gases to pass through it
Ascending Loop of Henle
is relatively impermeable to water but permeable to mineral ions.
Little water is reabsorbed if…
blood solute concentration is low
Osmoregulators
organisms that expend energy to maintain a homeostatic internal solute concentration.
Osmoconformers
organisms whose solute concentration is similar to that of the environment.
hyponatremia
low plasma concentration of sodium
Hypernatremia
occurs when there is a deficit of total body water relative to total body sodium content.
Cardiovascular drift
phenomenon characterized by a rise in heart rate & a fall in stroke volume over time during exercise
Macronutrients
nutrients that our body needs in large amounts to maintain health.
These include:
Carbohydrates
Fats
Proteins
Water
undernutrition
hunger
malnutrition
vitamin defiency
overnutrition
obesity
Recomended macronutrients per day of carbohydrate
50-60%
Recomended macronutrients per day of protein
12-15%
Recomended macronutrients per day of fat
less than 30%
Micronutrients
vitamins, minerals, trace elements
Anabolic reactions
Uses energy to build complex molecules (polymer chains) from simpler ones. They do so through condensation reactions. These reactions remove water (H2O) between monomers & then form a new covalent bond.
Catabolic reactions
break down complex molecules into simpler ones, which releases energy. They do so through hydrolysis. Hydrolysis is the opposite of condensation. Polymers are broken down by adding H2O & breaking covalent bonds.
Condensation reaction
reactions that remove water between monomers and then form a new covalent bond.
Hydrolysis
Polymers broken down by adding H2O and breaking covalent bonds
Carbohydrates
Made up of C, H, O
are organic compounds synthesized by plants from water & CO2 using solar energy.
100g of carbohydrate = 1760kj
Monosacchrides
single sugar molecules
glucose, fructose, gluctose
Disaccharides
form when 2 monosaccharides link together through condensation
Sucrose
formed from glucose and fructose
lactose
formed from galacose and glucose
maltose
formed from 2 gluose monomers
Oligosaccharides
form when 3-9 sugars are joined together through condensation.
ex. maltodextrin
Polysaccharides
form when 10 or more sugars are joined togetherthrough condensation
ex. glycogen, starch, cellulose
dietary fiber
poorly digestible, found in cell walls of plants, plays role in prevention of disease
intake of 100g or fat+ 4,000kj
Fatty Acid
chains of carbon atoms with hydrogen attached, and a methyl group (CH3) + carboxyl group (COOH) on each end
Saturated Fatty Acid
have a maximum number of C-H bonds. So they only have single-covalent bonds and a relatively linear.
Unsaturated fatty acid
have double covalent bonds which affects their shape
Monounsaturated
only one double bond
Polyunsaturated
multiple double bonds
Omega-3 Fatty acids
Polyunsaturated’s that have the first double bond located between the 3rd and 4thcarbon atom form the mathyl end
Omega-6 Fatty acid
Polyunsaturated that have thrie first double bond located between the 6 and 7th carbon atom from methyl end.
Triglyceride
molecules are the main component of fats & oils.
They are formed through the condensation of three fatty acids & glycerol.
They are broken down & stored in adipose tissue.
Joined by an ester linkage between the -COOH of the fatty acid & the -OH of the alcohol.
Steroid
Lipids with four fused rings.
Cholesterol
Sex hormones
Proteins
the second most abundant compounds in the body.
Water is the most abundant
Contain atoms of C, H, O, N, (S)
Proteins are made of monomers called
amino acids (AAs).
Intracellular
it acts as a medium for vital biochemical reactions.
Extracellular
Transport of nutrients, metabolites, waste products, hormones, & respiratory gases.
Thermoregulation (sweat) & excretion (urine, feces).
Cell-cell & cell-environment communication
Lubrication of joints & sliding surfaces.
Vitamin D
produced through precursors in the skin in combination with sunlight.
Vitamin B (niacin)
synthesized from the AA tryptophan.