CC SPH EXAM 8 (Liver Function Tests)

total protein

Hemolysis may falsely elevate concentration

Albumin

Hemolysis may falsely elevate concentration

Albumin

Contribute to plasma oncotic pressure

Albumin/ Globulin Ratio

Determined to validate if globulin is higher than albumin

cirrhosis, multiple myeloma, waldenstrom’s macroglobulinemia

inverted A/G ratio

1:3-3:1

normal values of Albumin/ Globulin ratio

hepatic cirrhosis

Low TP + Low albumin =

indirect bilirubin

type of bilirubin: Hemobilirubin

Indirect bilirubin

type of bilirubin: Slow reacting

Indirect bilirubin

type of bilirubin: prehepatic bilirubin

direct bilirubin

type of bilirubin: cholebilirubin

direct bilirubin

type of bilirubin: one minute/ prompt bilirubin

direct bilirubin

type of bilirubin: Post hepatic bilirubin/heoatic

bilirubin/obstructiveand regurgitive

bilirubin

PRE HEPATIC JAUNDICE

This condition produces increased serum unconjugated bilirubin.

hepatic jaundice

Exhibits increases in both unconjugated and conjugated bilirubin levels

post hepatic jaundice

Causes increased conjugated bilirubin levels in

serum and urine, but low urobilinogen levels in

urine and colorless stool

unconjugated (B1)

type of jaundice: Hemolytic anemias, newborns, hereditary

alteration of rate of conversion, medications

Conjugated (B2)

type of jaundice: Bile duct obstruction, some case of hepatitis, medication

hepatitis

Increases in Both fraction of bilirubin (B1 & B2)

unconjugated

cannot be excrete in the urine, so there is NO URINARY BILIRUBIN

unconjugated bilirubin

cannot be broken down by intestinal bacteria so there is NO URINARY UROBILINOGEN