physiology

TRPV1 is activated by

Ans warm capsacin H+ion more than 43degree C

Which receptor detects moderate cold 8-28 degree c

TRPM

Bradykinin acts via which receptor subtype

B1 B2

NGF STIMULATES NOCICEPTOR THROUGH

TRKA

Hyperalgesia

Exagerrated response to a noxious stimulus

Types of proprioceptor

1. Muscle spindle

2. Golgi tendon organ

3. Joint capsule recptor

4. Important - Aalpha will be efferent to extrafusal fibre

5. Agamma Y- efferent to muscle spindle

Muscle spindle intrafusa fibre - nuclear bag 1.dynamic 2.static Nuclear chain- static

and 1a - for both velocity length increase in both static nuclear bag and static nuclear chain length 11- reaponsible for length incre in nuclear bag static and nuclear chain static

GLUT 4

Insulin responsive glut muscle and adipose tissue

Q2.has the best prognosis among incomplete spinal cord injuries.

Many patients regain the ability to walk

Ans. Brown-Séquard syndrome

Brown-Séquard Syndrome

Cause:

• Stab injury (classic)

• Tumor

• MS

• TB spine

• Cervical disc

Motor:

Ipsilateral UMN below lesion

LMN at level

Posterior Column:

Ipsilateral loss

Pain:

Contralateral loss

Starts 1–2 segments below lesion

IOC:

MRI spine

Prognosis:

Best among incomplete cord injuries