RNA Quality Control and Elimination

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4 Terms

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How are unneeded RNAs eliminated?

Unneeded or faulty RNAs are degraded by nucleases after decapping or deadenylation, or through RNA interference by siRNAs and miRNAs.

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What role does the poly(A) tail play in RNA stability?

A long poly(A) tail stabilizes mRNA, while shortening of the tail signals degradation.

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How are HIV transcripts exported from the nucleus?

HIV uses the Rev protein, which binds to the Rev Response Element (RRE) on unspliced or partially spliced viral RNAs, allowing them to bypass normal quality control and exit the nucleus.

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