Genomics Final

What are the indications for Aripiprazole?

schizophrenia, bipolar disorder, major depressive disorder, irritability associated with autistic disorder, and in the treatment of Tourette Syndrome

How does Aripiprazole work?

A partial D2 agonist, which stabilizes dopamine signaling. Maintains some dopamine activity in the nigrostriatal and mesocortical pathways causing fewer extrapyramidal symptoms. Also has high affinity for 5-HT2alpha antagonist, and moderatelt blocks the alpha 1 adrenergic and H1 histmaine receptors which may account for lower incidence of orthostatic hypotension and sedation compared with other antipsychotics

What are the US FDA reccomendations for CYP2D6 ultra rapid

Name some CYP2D6 alleles have been associated with no activity / reduced activity / normal activity

What genotypes are associated with ultra-rapid CYP2D6 activity?

What unique CYP2D6 are associated with Asians,Africans, or Middle Easterners?

Name a challenge associated with testing for CYP2D6 alleles

What are some notable adverse events associated with aripiprazole therapy (concerning CYP2D6 activity / pregnancy or nursing status etc)

Is aripiprazole a prodrug/ is its metabolite active?

No, aripiprazole is not a prodrug. The aprent drug is pharmacologically active. It has one activate metabolite, dehydroapiprazole, which contributes to overall activity but to a less extent than the parent drug

Name some relevent reccomended dosing changes when CYP2D6 and/ or CYP3A4 inhibitors are administered along with Aripirazole

Strong CYP2D6 inhibitor (fluoxentine, paroxetine, quinidine) : reduce dose by 50%

Strong CYP3A

Name the common pharmacotherapeutic approaches to asthma management

Name the most notable genomic polymorphisms that influence outcomes following treatment with B2-adrenergic agonists.

How does THr164Ille impact the second messenger

What is the ethnic distribution of teh variant at codon 16