S.PYOGENES CLINICAL INFECTION

What is Streptococcal Toxic Shock Syndrome (STSS)?

A severe condition where the entire organ system collapses, often leading to death.

What organism causes STSS?

Streptococcus pyogenes.

What toxin is primarily responsible for STSS?

Streptococcal pyrogenic exotoxin A (SpeA).

What is the function of SpeA in STSS?

Acts as a superantigen, overstimulating the immune system and triggering massive cytokine release.

What is Streptococcal Toxic Shock Syndrome (STSS)?

A severe condition where the entire organ system collapses, often leading to death.

What organism causes STSS?

Streptococcus pyogenes.

What toxin is primarily responsible for STSS?

Streptococcal pyrogenic exotoxin A (SpeA).

What is the usual portal of infection in STSS?

Often unknown, but minor injuries or surgical wounds may be implicated.

What are the initial infections that may lead to STSS?

Pharyngitis, peritonitis, cellulitis, and wound infections.

STSS may develop symptoms similar to what other condition?

Staphylococcal Toxic Shock Syndrome (TSS).

What are the two major poststreptococcal sequelae?

Rheumatic Fever (RF) and Acute Glomerulonephritis (AGN).

Rheumatic Fever follows what type of S. pyogenes infection?

Pharyngitis (throat infection).

What are the main symptoms of Rheumatic Fever?

Fever and inflammation of the heart, joints, blood vessels, and subcutaneous tissues.

What is the most serious complication of Rheumatic Fever?

Chronic, progressive damage to the heart valves (Rheumatic Heart Disease).

Acute Glomerulonephritis follows what types of S. pyogenes infections?

Cutaneous (skin) or pharyngeal (throat) infections.

Who is more commonly affected by Acute Glomerulonephritis?

Children more than adults.

What causes the kidney damage in AGN?

Immune complex deposition in the glomeruli, leading to inflammation.

What are common symptoms of AGN?

Edema, hematuria, proteinuria, and hypertension.