synthesis and rxns of amides

most commonly made with

acid chlorides and amine nu with base

r-nh2 and na2co3

acylation of an amine (review) rxns of amines

ester to amide

addn/elim

r-nh2

anhydride (tbu) to amide

r-nh2 addn/elim (new)

r-c≡n to amide

acid water or naoh
nitriles hydrolysis (new)
basic amid eis formed

acidic amide will hydrolyze to cooh

r-cooh to amide

fast acid base with r-nh2

then slow addn hard to make amide (addn with h3n+-R) and HIGH heat difficult to do

amide hydrolysis acidic

with acid water to cooh

amide hydrolysis basic

carboxylate with naoh so slow rxn unlikely to occur

amide with br2 and naoh

r-nh2 when r=h
hofman rearragnemtnet (review)

amide + pocl3

r-c≡n and HCl

synthesis of nitriles (new)

amide + lialh4

witha cid water makes amine

reduciton via addn elim (diff)