NU553 Unit 4 GERD and Peptic Ulcer Disease PUD Advanced Pharmacology and Pharmacotherapeutics Exam 2

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High fat meals GERD effect?

Delay gastric emptying decrease LES tone

GERD treatment duration if effective?

4 to 16 weeks

Best test confirm H pylori eradication?

Urea breath test

Avoid lying down after meals how long?

3 hours

Misoprostol use?

Prevent NSAID ulcers

GERD cancer complication?

Esophageal adenocarcinoma

First line H pylori therapy?

PPI plus two antibiotics

Fundoplication purpose?

Surgical LES reinforcement

Why avoid metoclopramide GERD?

Side effects outweigh benefit

GERD therapy goals?

Relieve symptoms heal prevent complications

Metronidazole alcohol reaction?

Disulfiram like

H2 blocker renal adjust?

Famotidine

NSAID ulcer prevention?

Misoprostol or COX2 inhibitor

Avoid clarithromycin retreatment why?

Resistance

Why not PRN PPI?

Delayed onset

Second line GERD PPI adjustment?

Increase to twice daily

Duodenal ulcer timing?

1 to 3 hours after meals

Duodenal ulcer pain pattern?

Relieved by food

COX2 inhibitor?

Celecoxib

Barrett esophagus definition?

Columnar metaplasia

Drugs worsen GERD?

Calcium channel blockers benzodiazepines tricyclic antidepressants

GERD diagnosis initial?

Empiric therapy

Misoprostol mechanism?

Prostaglandin analog

PPI long term electrolyte risk?

Low magnesium

Esophageal irritants drugs?

NSAIDs potassium

NSAID ulcer mechanism?

COX1 inhibition

Hold PPI before UBT?

7 to 14 days

Magnesium antacid effect?

Diarrhea

H2RA trial duration?

2 weeks

Bisphosphonate risk?

Esophageal irritation

Normal endoscopy GERD?

Does not exclude

PPI timing?

30 to 60 minutes before meals

Foods avoid GERD?

Fat caffeine alcohol peppermint

Alarm PUD symptoms?

Weight loss bleeding anemia vomiting

PPI long term risks?

Fractures infections low magnesium

Sucralfate timing?

Empty stomach

GERD mechanism?

LES relaxation

Smoking GERD effect?

Delayed emptying

Cimetidine risk?

CYP interactions

Triple therapy duration?

10 to 14 days

H pylori survival enzyme?

Urease

GERD atypical symptom?

Chronic cough

Silent GERD meaning?

No heartburn

H2RA tolerance?

Tachyphylaxis

PUD causes?

H pylori NSAID stress

Avoid sodium bicarbonate pregnancy?

Fluid overload alkalosis

Gastric outlet obstruction signs?

Vomiting early satiety

Bismuth side effect?

Black stool

Least CYP PPI?

Pantoprazole

Avoid bismuth children?

Reye syndrome risk

Misoprostol contraindication?

Pregnancy

PUD therapy goals?

Relieve heal prevent recurrence

Avoid tetracycline dairy why?

Reduced absorption

Avoid tetracycline children why?

Tooth discoloration

Clopidogrel PPI choice?

Pantoprazole

Antacid constipation type?

Aluminum

GERD typical symptoms?

Heartburn regurgitation

Dexlansoprazole advantage?

Flexible dosing time

H2RA onset?

1 to 2 hours

Antacid mechanism?

Neutralize acid

NSAID lowest CV risk?

Naproxen

Mild GERD treatment?

Lifestyle and antacids

Obesity GERD cause?

Increased abdominal pressure

PUD main causes?

H pylori NSAIDs stress

Separate antacids why?

Drug absorption interference

Omeprazole clopidogrel issue?

CYP inhibition

Sucralfate renal risk?

Aluminum toxicity

PPI mechanism?

Proton pump inhibition

Sucralfate mechanism?

Protective barrier

Cimetidine endocrine effects?

Gynecomastia impotence

Amoxicillin H pylori reason?

Works better at higher pH