Chapter 11b: Viruses

viruses use this in order to gain entry into cells

receptor mediated endocytosis

the drop in pH causes what

release of nucleic acid

cytosol importance in the infectious cycle

host defense

if you’re a DNA virus you need to enter the

nucleus of the host cell where the transcription cells are found

allows the membrane to fuse with the host plasma membrane and it’s RNA directly penetrate the cell

CD4 protein

opens and release it’s nucleic acid so it can be translated

protein pores

virus exit options

exocytosis, budding, and lysis

part of the host cell plasma membrane that will surround the capsid

envelope

captured host cell and use it as a viral production plant

budding

process where vesicles within the cell that fuse with the plasma membrane and release their contents outside the cell

exocytosis

What describes how the endosome releases viral nucleic acid

endosome formation causes a decrease in pH

have a receptor that the virus can bind to

susceptible

cells that dont have the receptor or the virus to bind to

resistant cells

cells that have the capacity to replicate virus

permissive cells

the only cell that can take up a virus particle and replicate it

susceptible and permissive cells

affects multiple systems

systemic virus

invasive vs virulence

invasive- ability of a virus to penetrate host tissues and spread throughout the body

virulence- degree of damage a virus can cause to it’s host

benign vs malignant

benign-locally dividing

malignant-locally dividing and spreading

trigger an infected cell to stop growing and lead to apoptosis(cell death)

p53

blocks attachment molecule(arildone)

attachment antagonists

neutralize acid environment (amantadine, rimantadine)

inhibit uncoating

inhibit DNA/RNA synthesis

activation by photophosphorylation of drug by viral kinases