Regulation of Calcium and Phosphate Metabolism

key players in normal mineral homeostasis

calcium- physiologic functions

calcium distribution

forms of calcium in blood

laboratory measurement of serum (plasma) calcium concentration

calcium assays

measurement of serum calcium concentration influenced by changes in

influence of serum albumin concentrations

corrected calcium

serum calcium measurement- acidemia

serum calcium measurement- alkalosis

serum calcium measurement- influence of plasma anion (phosphate) concentrations

complex clinical situations

calcium handling

-GI tract

-bone

-kidney

intestinal calcium handling- intestinal absorption depends on

intestinal calcium handling- absorption and active transport

bone calcium handling

renal calcium handling

renal calcium handling- active reabsorption  

calcium homeostasis in adult with calcium intake 1000mg/day

phosphorus- physiologic functions

serum phosphate

phosphate handling

-GI tract

-skeleton

-kidney

intestinal phosphate handling

phosphate absorption directly related to

-intake

skeletal phosphate handling

renal phosphorous handling

skeleton

skeleton- function

3 types of bone cells

3 major functions of bone cells

bone remodeling cycle

RANK and RANKL

calciotropic hormones

PTH

PTH function and regulation

mechanism of calcium sensing and PTH secretion

mechanism of PTH secretion

PTH receptor

PTH- target organs

PTH- target organs- bone

hormonal regulation of calcium by PTH- overview

vitamin D

synthesis of vitamin D

regulation of vitamin D synthesis

regulation of 1alpha hydroxylase

actions of vitamin D

targets of vitamin D

calcitonin

actions of calcitonin

hormones and factors involved in phosphate regulation

-phosphate

-PTH

-vitamin D

-FGF-23

phosphate regulation of phosphate

PTH regulation of phosphate

FGF-23

vitamin D regulation of phosphate by targets

overview of phosphate metabolism

PTH actions- organ, site, action, effect

vitamin D actions- organ, site, action, effect

disorders of bone and mineral metabolism- disorder, pathophysiology, effect

summary