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20.1A: Major Functions of the Heart
Pumping Blood: The heart ensures blood circulation throughout the body.
Oxygenation of Blood: The right side pumps deoxygenated blood to the lungs.
Delivery of Nutrients: The left side pumps oxygenated blood to tissues.
Removal of Waste: Facilitates the removal of carbon dioxide and metabolic wastes.
Maintains Blood Pressure: Ensures consistent blood flow by maintaining pressure.
Size: Approximately the size of a fist (about 250-350 grams).
Shape: Cone-shaped, with a pointed apex directed downward.
Location: In the thoracic cavity, between the lungs in the mediastinum, slightly left of the midline, behind the sternum, and above the diaphragm.
20.2B: Importance of Knowing the Heart's Location
Medical Procedures: Crucial for CPR, defibrillation, and surgeries.
Diagnosis: Helps in interpreting symptoms like chest pain.
Injury Avoidance: Prevents harm during chest-related interventions.
20.3A: Structure of the Pericardium
Structure: A double-layered sac surrounding the heart.
Fibrous Pericardium: Outer tough layer, anchors the heart.
Serous Pericardium: Two layers (parietal and visceral) with pericardial fluid in between, reducing friction.
20.3B: Layers of the Heart Wall
Epicardium: Outermost layer, provides protection and lubrication.
Myocardium: Thick muscular middle layer, responsible for contraction.
Endocardium: Inner layer lining the chambers and valves, minimizes resistance to blood flow.
20.3C: Large Veins and Arteries
Veins Entering the Heart:
Superior and Inferior Vena Cava (to the right atrium).
Pulmonary Veins (to the left atrium).
Arteries Exiting the Heart:
Pulmonary Arteries (from the right ventricle).
Aorta (from the left ventricle).
20.3D: Coronary Arteries
Location: Originate from the base of the aorta.
Blood Flow: Supply oxygenated blood to the myocardium.
20.3E: Cardiac Veins
Location: Drain deoxygenated blood from the myocardium into the coronary sinus.
Blood Flow: Return blood to the right atrium.
20.3F: Structure and Functions of Heart Chambers
Atria: Receive blood (right from the body, left from the lungs).
Ventricles: Pump blood (right to the lungs, left to the body).
20.3G: Heart Valves
Atrioventricular (AV) Valves: Tricuspid (right) and Mitral (left); prevent backflow into atria.
Semilunar Valves: Pulmonary and Aortic; prevent backflow into ventricles.
20.4A: Blood Flow Through the Heart
Deoxygenated blood enters right atrium → tricuspid valve → right ventricle → pulmonary valve → lungs via pulmonary arteries.
Oxygenated blood enters left atrium → mitral valve → left ventricle → aortic valve → body via aorta.
20.5A: Heart Skeleton
Structure: Fibrous connective tissue framework.
Functions:
Electrical insulation.
Support for valves.
Attachment for cardiac muscles.
20.5B: Cardiac Muscle Cells
Structural Features: Striated, branching, single nucleus, intercalated discs.
Functions: Enable synchronized contractions.
20.5C: Cardiac vs. Skeletal Muscle
Cardiac Muscle: Involuntary, intercalated discs, long refractory period.
Skeletal Muscle: Voluntary, multinucleated, shorter refractory period.
20.5D: Conducting System
Structure: Includes SA node, AV node, bundle of His, bundle branches, Purkinje fibers.
Function: Coordinates contraction.
20.6A: Autorhythmicity and Pacemaker Potential
Autorhythmicity: The heart generates its own electrical impulses.
Pacemaker Potential: SA node's cells spontaneously depolarize.
20.6B: Action Potentials in Cardiac Muscle
Phases:
Depolarization (Na+ influx).
Plateau (Ca2+ influx).
Repolarization (K+ efflux).
Long Refractory Period
Importance: Prevents tetanus, ensures effective pumping.
20.6D: Electrocardiogram (ECG)
Waves:
P wave: Atrial depolarization.
QRS complex: Ventricular depolarization.
T wave: Ventricular repolarization.
20.7A: Cardiac Cycle
Phases:
Atrial Systole.
Ventricular Systole.
Diastole.
Relation to ECG: Aligns with waves and intervals.
20.7B: Heart Sounds
Lub (S1): AV valves closing.
Dub (S2): Semilunar valves closing.
MAP: Average blood pressure in arteries.
Cardiac Output (CO): Heart rate × stroke volume.
Peripheral Resistance: Resistance in blood vessels.
20.8B: MAP and Blood Flow
Role: Drives blood through systemic circulation.
20.9A: Intrinsic Regulation
Mechanism: Frank-Starling law; stroke volume increases with venous return.
20.9B: Extrinsic Regulation
Neural (sympathetic/parasympathetic).
Hormonal (epinephrine).
Ionotropic (external substances).
20.10A: Effects of Blood Chemistry
Changes in pH, CO2, O2 affect heart rate via chemoreceptors.
20.10B: Extracellular Ions
High K+: Decreases heart rate.
High Ca2+: Strengthens contractions.
20.10C: Temperature Effects
High temperature: Increases heart rate.
Low temperature: Decreases heart rate.
Anatomy and Physiology 2
A course focusing on the structure and functions of body systems, emphasizing interactions among systems to maintain homeostasis.