Platelet Production

LD-CFU-Meg cells undergo ______.

endocytosis

Endocytosis is unique to ______.

megakaryocytes

During endomitosis, the cytoplasm ______ and DNA ______.

grows, replicates

Unlike mitosis, endomitosis doesn't include _______.

division

Endomitosis causes the ______ of cytoplasm.

budding off

These separated portions of cytoplasm become ______.

platelets

What cytokines are involved in megakaryopoieses?

TPO, Meg-CSF, IL-3

The spleen is involved in ______.

platelet storage

Thrombopoietin (TPO) induces stem cells to make ______.

megakaryocyte progenitors

TPO induces megakaryocyte progenitors to become ______ and ______.

megakaryoblasts, megakarocytes

TPO induces megakaryocyte ______ and ______.

proliferation, maturation

TPO induces ______.

thrombopoiesis (platelet release)

TPO has a half-life of ______ hours.

30

When platelets are increased, TPO ______.

decreases

TPO binds to ______ and is removed by them.

platelets

There are normally ______uL of platelets.

150,000-450,000

The mean platelet volume is ______fL.

8-10

A thrombocyte is a ______.

platelet

Thrombocytopenia is when there are ______ amounts of platelets.

low

Thrombocytosis is when there are ______ amounts of platelets.

high

The dense tubular system and surface-connected canalicular system are responsible for moving ______ out of megakaryocyte.

platelets

What are the three functions of platelets?

- Adhesion

- Aggregation

- Secretion

Platelets adhere to damaged ______ walls.

blood vessel

Platelets stick to ______ and change shape extending pseudopodia.

each other

Platelets secrete substances to facilitate activation of the ______.

coagulation cascade

Megakaryoblast (MK I)

Promegakaryocyte (MK II)

Megakaryocyte (MK III)

Terminal Megakaryocyte (MK-III)