HEART MEDICATIONS

Ranolazine

Ranexa — Antianginal agent

Ranolazine PO/Function/Common Use

PO — Reduces cardiac demands (sodium channels) — Chronic stable angina (stable chest pain)

Ranolazine Adverse Drug Reactions/Special Considerations

Increased risk: cardiac arrhythmia (QTc prolonged) — Dizziness, headache, nausea, constipation — Many drug interactions

Isosorbide mononitrate

Imdur — Antianginal/vasodilator

Isosorbide mononitrate PO/Function/Common Use

PO — Vasodilates the veins — Chronic stable angina (stable chest pain), heart failure

Isosorbide mononitrate Adverse Drug Reactions/Special Considerations

— Headache, dizziness — DO NOT give with PDE5 inhibitors (e.g., sildenafil)

Isosorbide dinitrate

Isobid — Antianginal/vasodilator

Isosorbide dinitrate PO/Function/Common Use

PO — Vasodilates the veins — Chronic stable angina (stable chest pain), heart failure

Isosorbide dinitrate Adverse Drug Reactions/Special Considerations

— Headache, dizziness — DO NOT give with PDE5 inhibitors (e.g., sildenafil)

Propafenone

Rythmol — Antiarrhythmic (Class Ic)

Propafenone PO/Function/Common Use

PO — Slows down the heart rate (sodium channels) — Arrhythmia (lone atrial fibrillation)

Propafenone Adverse Drug Reactions/Special Considerations

Arrhythmia, chest pain — Metallic taste, nausea, vomiting, dizziness — No special considerations

Amiodarone

Cordarone, Pacerone — Antiarrhythmic (Class III)

Amiodarone PO/Function/Common Use

PO, IV — Slows down the heart rate (multiple ways) — Arrhythmia (many types)

Amiodarone Adverse Drug Reactions/Special Considerations

Arrhythmia, lung toxicity (shortness of breath), liver toxicity — Nausea/vomiting, skin discoloration, increased or decreased blood thyroid hormone — Many drug interactions

Digoxin

Digitek, Digox, Lanoxin — Antiarrhythmic agent

Digoxin PO/Function/Common Use

PO, IV — Reduces heart rate and strengthens stroke volume — Arrhythmia (atrial fibrillation), heart failure

Digoxin Adverse Drug Reactions/Special Considerations

Stupor (barely conscious) — Nausea/vomiting, visual disturbance, drowsiness, confusion — Many drug interactions; check blood level