Table 13A.1: Comparison of Osteoarthritis + Rheumatoid Arthritis (PAZ Textbook)

Osteoarthritis

Onset:

- majority of adult age >65

- gradual onset

Incidence: 12% US adults

Gender:

- age <45: predominantly males

- age >45: predominantly females

Etiology:

- inflammatory response

- genetic

- environmental factors

Manifestations:

- unilateral joint involvement

- affects: spine, hip, knees, feet + hands

- inflammation present in 10% of cases

- brief morning stiffness

Systemic Symptoms: none

Lab Values

- ESR: mildly-moderately increased

- rheumatoid factor: absent

what is the ONSET AGE associated with OSTEOARTHRITIS

adult age >65 (majority)

is the onset GRADUAL/SUDDEN with OSTEOARTHRITIS

gradual onset

what is the INCIDENCE of OSTEOARTHRITIS

12% US adults

at what AGE are MALES predominantly at high risk of OSTEOARTHRITIS

age <45

at what AGE are FEMALES predominantly at high risk of OSTEOARTHRITIS

age >45

is there UNILATERAL/BILATERAL joint involvement with OSTEOARTHRITIS

unilateral joint involvement

what 5 joints are commonly affected with OSTEOARTHRITIS

1. spine

2. hips

3. knees

4. feet

5. hands

what PERCENTAGE of INFLAMMATION is present in OSTEOARTHRITIS cases*

inflammation present in 10% of cases

is there BRIEF/PROLONGED morning stiffness associated with OSTEOARTHRITIS

brief morning stiffness

are there SYSTEMIC SYMPTOMS present with OSTEOARTHRITIS

no systemic symptoms present

what is the presence of ESR associated with OSTEOARTHRITIS

mildly-moderately increased

is the RHEUMATOID FACTOR absent/present associated with OSTEOARTHRITIS

rheumatoid factor ABSENT

Rheumatoid Arthritis

Onset:

- adult: ages 25-50

- sudden onset

Incidence: 1-2% US adults

Gender:

- female:male ratio 3:1

Etiology: autoimmune process with multifactorial components

Manifestations:

- symmetrical, bilateral joint involvement

- affects: any joint, predominantly upper extremity joints

- inflammation present in most cases

- prolonged morning stiffness

Systemic Symptoms: fatigue, malaise, weight loss + fever

Lab Values

- ESR: increased during inflammatory process (exacerbation)

- rheumatoid factor: present but not diagnostic for disease

what is the ONSET AGE associated with RHEUMATOID ARTHRITIS

adults 25-50 years old

is the onset GRADUAL/SUDDEN with RHEUMATOID ARTHRITIS

sudden onset

what is the INCIDENCE of RHEUMATOID ARTHRITIS

1-2% US adults

what is the FEMALE:MALE RATIO of RHEUMATOID ARTHRITIS

3:1 (female:male)

what is the ETIOLOGY of RHEUMATOID ARTHRITIS

autoimmune process with multifactorial components

is there UNILATERAL/BILATERAL joint involvement with RHEUMATOID ARTHRITIS

symmetric bilateral joint involvement

what joints are affected by RHEUMATOID ARTHRITIS

any joints

what joints are predominantly affected by RHEUMATOID ARTHRITIS

upper extremity joints

is INFLAMMATION present in MOST CASES/NO CASES regarding RHEUMATOID ARTHRITIS

inflammation present in most cases

is there BRIEF/PROLONGED morning stiffness associated with RHEUMATOID ARTHRITIS

PROLONGED morning stiffness

what are the 4 SYSTEMIC SYMPTOMS associated with RHEUMATOID ARTHRITIS

1. fatigue

2. malaise

3. weight loss

4. fever

is ESR increased/decreased regarding RHEUMATOID ARTHRITIS

increased

during what process is ESR INCREASED regarding RHEUMATOID ARTHRITIS

inflammatory process (exacerbation)

is the RHEUMATOID FACTOR present/absent regarding RHEUMATOID ARTHRITIS

present

what lab value is NOT a diagnostic tool for RHEUMATOID ARTHRITIS

rheumatoid factor