BB 13: Blood and Blood Components (Pt. 2)

a ____ product is made by spinning the WB product using high RPM (hard spin) which results in no RBCs, WBCs, or PLTs.

plasma

what product is used in replacement of all coagulation factors?

FFP

heat liable factors are V, VII, and VIII. what is the half life of factor V?

12 hours

heat liable factors are V, VII, and VIII. what is the half life of factor VII?

5 hours

heat liable factors are V, VII, and VIII. what is the half life of factor VIII?

10 hours

what product is used in massive hemorrhage - hypovolemia?

FFP

for FFP, group ____ plasma can be used on ANY trauma patient, regardless of patient’s blood type.

A

what product re-establishes normal coagulation scheme in massive hemorrhage?

FFP

what is the storage temperature for FFP?

<-18°C

immediately after collection, WB must be rapidly cooled (via chest containing wet ice or BB fridge) to a temperature of ____ for FFP.

1-6°C

what is the frozen expiration of FFP?

1 year

what is the thawed expiration of FFP?

24 hours

at what temperature must FFP be kept at when thawed?

1-6°C

to thaw FFP, use a ____°C water bath.

37°C

what product is frozen within 24 hours of collection?

PF24

what product is used only as liquid plasma because the heat-liable coagulation factors are essentially gone, but the more stable coagulation factors are still present (e.g., factors II, VII, IX, X, and XI)?

PF24

what is the storage temperature of PF24?

<-18°C

immediately after collection for PF24, WB must be stored at ____°C.

1-6°C

what is the expiration of thawed plasma for FFP or PF24?

4 days after initial thaw date

thawed plasma have ____ factor V and VII levels.

reduced

what is the storage temperature of FDP?

room temperature

what is the transport temperature of FDP?

room temperature

what is the expiration of FDP?

2 years

what product is used for replacement of factor VII or fibrinogen or vWF (primarily fibrinogen)?

cryoprecipitate

each unit of cryo can raise the ____ level 5-10mg/dL.

fibrinogen

what product can be used to make biologic fibrin glue in certain surgeries to stop oozing blood?

cryoprecipitate

cryoprecipitate is made from what product?

FFP

what is the storage temperature of cryoprecipitate?

<-18°C

what is the frozen expiration of cryoprecipitate?

1 year

when cryoprecipitate is thawed, store at ____°C.

20-24°C

the expiration for an individual unit of thawed cryo is ____ post thaw and date.

6 hours

the expiration for pooled thawed cryo in an open system post open time and date is ____.

4 hours

what product contains the following:

• 700mg fibrinogen

• 200IU Factor VIII

• vWF

• some plasma

cryoprecipitate

what device can connect 2 separate blood tubing without breaching the integrity of either container/aliquot?

SCD

with the use of a ____, a closed system is maintained and this type of environment does not affect the original expiration date of the product.

SCD

for the use of a SCD, if the seal is broken or leaking, the expiration date of the product is reduced/changed to ____ and a new hermetic seal is created.

24 hours

fibrinogen complex cannot be used for the replacement of factor VIII. true or false?

true

fibrinogen complex cannot be used for the replacement of factor XIII. true or false?

false

what is the storage temperature for fibrinogen complex?

<-18°C

what is the expiration for frozen fibrinogen complex?

1 year

what is the post thaw storage temperature of fibrinogen complex?

20-24°C

what is the post thaw expiration of fibrinogen complex?

5 days

what product contains the following:

• 3000mg fibrinogen

• vWF

• some plasma

fibrinogen complex

the ____ machine has the capability to select certain blood elements to be collected and return the remaining blood to the donor.

apheresis

the donation/product collection time for _____ products is usually hours.

apheresis

____ products are:

• larger in volume

• have increased quantities of cellular elements

• uses less manipulation in processing the product when compared to the WB-derived components

apheresis

what product can collect both non-leukoreduced products and leuko-reduced products without the added filtration processing step?

apheresis

plateletpheresis (PLTPH) is equivalent to ____ platelet concentrates.

4-6

PLTPH raises platelet count after transfusion to ____/uL in a 70kg adult.

40,000

what is used to determine platelet refractoriness?

CCI

what is the storage temp of PLTPH?

20-24°C

what is the expiration of PLTPH?

5 days

what is the expiration of PLTPH with bacterial reduction?

7 days

what is the transport temperature of PLTPH?

20-24°C

the QC requirement of PLTPH is ____ platelets.

>3.0 × 10¹¹

the QC requirement of PLTPH is a pH of ____.

>6.2

what test helps establish the difference between physical v. immunized cause for platelet transfusion response?

CCI

what is based on the number of platelets transfused and the size of the patient (BSA) and is used to measure platelet refractoriness?

CCI

normal platelet CCI is ____ uL and above.

>7500

normal platelet CCI is ____ uL and above at 24 hours.

>5000

abnormal/refractoriness is denoted by ____uL for CCI.

<5000

the platelet count increment is less affected by physical attributes where as the presence of ____ will be affected.

antibody

ABO antigens are on the platelet membrane, so ABO incompatible plasma may be a cause for a low platelet transfusion response. true or false?

true

what drug is normally used to treat multiple myeloma?

daratumumab

what drug effectively addressed platelet refractoriness, while exhibiting mild and tolerable drug side effects?

daratumumab

cold stored plateletpheresis are stored at 1-6°C with no agitation. true or false?

true

what product is used in treatment of profound neutropenia (<500/uL or 0.5 × 10⁹/L) in the presence of bacterial or fungal infection unresponsive to antimicrobial therapy?

granulocytes apheresis

transfusion of granulocytes apheresis should continue at least ____ until the infection is cured.

daily

because most recipients of granulocytes apheresis are immunosuppressed, the product should be ____ prior to prevent TA-GVHD.

irradiated

granulocytes apheresis should be stored at 20-24°C with agitation. true or false?

false

factor VIII and vWF (alphanate) can treat hemophilia ____ and vWF diseases.

A

factor IX (konyne) can treat hemophilia ____.

B

gamma globulin (gammagard) can treat ____ associated disease.

IgG