Innate Immunity

Chapter 16

Antibody-Mediated Immunity is derived from which of the following?

B cells

What do the lymph nodes, spleen, tonsils, and appendix have in common relative to immune function?

Macrophage storage

The ultimate source of Leukocytes are lymphoid stem cells.

False

Basophils, Eosinophils, and Mast Cells are all part of the Innate Immune System.

True

Which of the following does not function in both the Innate and Adaptive Immune Systems?

Mast cells

Which of the following is not on the list of other anti microbial substances?

Clotting factors

Interferons

Iron-binding proteins

Antimicrobial peptides

Complement system

Clotting factors

Lymph nodes are the sites of T Cell and B Cell activation.

True

Which of the following represent the correct order for phagocytosis?

Chemotaxis, adherence, ingestion, digestion

Which of the following is not a part of the 1st line of defense?

Physical factors

Chemical factors

Formed elements in blood

Normal microbiota

Constant flushing

Formed elements in blood

Which of the following is not a mechanism for microbial evasion of phagocytosis?

Protection via biofilms

Presence of capsule

Cytokine secretion

Secretion of leukocidins

Cytokine secretion

What is innate immunity?

defenses present at birth; rapid response; does not involve recognition of a specific microbe

What is adaptive immunity?

A specific response to a specific microbe; slower response; memory component

What are the physical factors in the 1st line of defense?

Intact skin, mucosal membranes

Cytokines are protein-based chemical messengers that allow for communication between cells of the immune system.

True

Which of the following have functions in both the innate and adaptive immune systems?

Dendritic cells

(Adaptive - T cells, innate - B, E, M cells)

All of the following are components of the inflammatory response except ___.

1. dilation of blood vessels

2. B cell activation to produce plasma cells

3. movement of leukocytes out of the circulatory system into the damaged area

4. chemotaxis

5. release of histamines and prostaglandins

B cell activation to produce plasma cells

The swelling associated with inflammation decreases when the fluid __.

moves into lymph capillaries

Which of the following is not true regarding B cells?

1. They are responsible for antibody formation.

2. They are responsible for the memory response.

3. They originate in bone marrow.

4. They recognize antigens associated with MHC-I.

5. They have antibodies on their surfaces.

They recognize antigens associated with MHC-I

Which of the following functions the site for lymphoid stem cell maturation into T cells?

Thymus

Function of basil cells

0.5-1.0% of all leukocytes in plasma

production of histamine

partly responsible for allergy symptoms

Which of the following is not part of the 1st line of defense against pathogens?

1. pluripotent stem cells

2. chemical factors

3. physical factors

4. constant flushing

5. normal microbiota

pluripotent stem cells

Function of eosinophils

2-4% of all leukocytes in plasma

Defend against larger parasitic invaders (e.g. Schistosoma mansoni) by releasing toxic proteins

Some phagocytosis

Function of mast cells

Found in tissues

Partly responsible for allergy symptoms (Trigger release of histamine, serotonin, cytokines, proteases)

One type of antigen-presenting cell (APC)