Chapter_11_Cell_Adhesion_and_Communication_S25__1_

Collagen is made by the __________, processed in the Golgi, and secreted by __________.

rough ER; exocytosis

Proteoglycans consist of a __________ protein core and long __________ chains.

polypeptide; carbohydrate

Integrins bind to ECM proteins such as __________ and __________.

fibronectins; laminins

Tight junctions create a __________ seal between two neighboring cells.

watertight

Cadherins are __________ dependent linking proteins involved in cell adhesion.

Ca+2

In desmosomes, proteins link to __________ filaments, whereas adherens junctions link to __________ filaments.

intermediate; actin

Signal reception occurs when a signaling molecule binds to its __________.

receptor

Lipid soluble signaling molecules, like hormones, bind __________ receptors inside the cell.

intracellular

G-proteins are activated by __________ and deactivate by __________.

GTP; GDP hydrolysis

Enzyme-linked receptors directly catalyze a reaction inside the __________.

cell

Ras exchanges GDP for __________ upon activation in a signaling cascade.

GTP

Second messengers such as __________ and __________ are involved in intracellular signaling pathways.

cAMP; cGMP

GPCR

DAG

GCPR

Secondary messangers: cAMP, Adenylyl cyclase, Trimeric G-protein, calcium ions

GPCR

phosphodiesterase

ELR

Cross phosphoralation, Ras, dimerization

Both

Activated G-protein, ATP, innapropriate signal= cancer

Signal deactivation

GTP hydrolized to GDP + pi, Ligand dissosociation

GCPR

Ligand dissosiciates, endocytosis

Receptor tyrosine kinase

phosphotase, endocytosis, ligand dissociate

Ras

Hydrolysis of GTP to GDP + pi

CAMP

phosphodiesterase

E2F

Ras binding

RB

phosphoralated

Cyclin/CDK complec

p16, p21, p27

cyclins

proteosomes

CDK

inhibitory phosphate