Antifungal notes

alopecia

partial or complete hair loss

Bronchiectasis

Chronic widening/damage of the bronchi

Cellulitits

Bacterial skin infection with pain, redness

Cholestasis

poor bile flow through biliary system

colonize

microorganisms live on/in a host without disease

demyelinating encephalopathy

brain dysfunction from myelin damage

dysgeusia

altered or lost sense of taste

fungicidal

kills fungal cells

fungistatic

slows the progression of fungal infection

keratin

structural protein in skin, hair, nails

leukoencephalopathy

disease of the brain’s white matter

lysis

breakdown of a cell

myalgia

muscle aches and pain

neutropenia

low neutrophil count

normal flora

microorganisms normally present in a healthy person

pericarditis

inflammation of the sac around the heart

secondary bacterial infection

new infection layered on an existing one

steven-Johnson syndrome

severe reaction causing skin blistering

fungal cell membranes are built with

ergosterol

systemic

affects internal organs; harder to treat, prolonged therapy

opportunistic

occurs when defenses are weak

non-opportunistic

occurs in any host

superficial

affects skin, scalp, nails, mucous membranes

Topical used for

localized superficial infections

oral use for

more extensive or systemic infections

iv used for

serious systemic infections

Allylamine class example

terbinafine (lamisil)

Azole Derivative class example

Ketoconazole (Nizoral)

Polyene macrolide class example

amphotericin B (Fungilin)