module 6: t cells

B cell maturation takes place in the ? while T cell maturation takes place in the ?.

bone marrow, thymus

True or False: B cells have a longer lifespan than T cells.

false

Changes in gene expression during T cell development is controlled by ? signaling.

notch

In T cell development, ? selection identifies double-positive thymocytes that recognize self-MHC and induces their survival.

In T cell development, ? selection identifies single-positive thymocytes that bind to self-MHC too strongly and eliminates them.

positive, negative

Place the different T cell phases in order from earliest to mature.

double neg, double positive, single positive, mature

The cells in the thymus that guide the development of T cells are called what?

thymic stromal cells

In both B cells and T cells, ? tolerance removes self-reactive lymphocytes in primary lymphoid tissues while ? tolerance removes self-reactive lymphocytes in the blood.

central, peripheral

True or False: The production of the αβ T cell receptor is favored during somatic recombination.

true

express CD4 coreceptor

helper

recognize pathogenic antigen: MHC II

helper

proliferate and differentiate into effector and memory cells when activated

helper

proliferate but don't differentiate when activated

regulatory

CD4 coreceptor recognizes MHC I and II

regulatory

controls immune cell activities

regulatory

proliferate and differentiate into cytotoxic effectors and memory cells when activated

cytotoxic

recognize peptide: MHC I complexes

cytotoxic

express CD8 coreceptor

cytotoxic