7.5 - TOXICOLOGY OF THERAPEUTIC DRUGS

0.0(0)
studied byStudied by 0 people
learnLearn
examPractice Test
spaced repetitionSpaced Repetition
heart puzzleMatch
flashcardsFlashcards
Card Sorting

1/6

encourage image

There's no tags or description

Looks like no tags are added yet.

Study Analytics
Name
Mastery
Learn
Test
Matching
Spaced

No study sessions yet.

7 Terms

1
New cards

cyclooxygenase

Salicylates (Aspirin)

Mechanism: Inhibits _ → ↓ thromboxane & prostaglandins

2
New cards

Reye’s syndrome

Salicylates (Aspirin)

Adverse Effects: GI disruption, ↓ platelet aggregation, _ _ risk

3
New cards

Mixed Acid Base Disorder

Metabolic acidosis

Respiratory alkalosis

Salicylates (Aspirin)

Toxic Effects: _ _ _ _

_ _ (acid ingestion, ↑ lactic acid, ↑ ketones),

_ _ (stimulates respiratory center)

4
New cards

Trinder reaction

enzymatic with salicylate hydroxylase

GC/LC

Salicylates (Aspirin)

Detection Methods: _ _ (chromogenic), _ with _ _ (↓A at 340 nm), _/_ (reference)

5
New cards

Hepatic biotransformation

Acetaminophen (Tylenol)

Mechanism: _ _; toxic pathway via MFO

6
New cards

Glutathione depletion

Acetaminophen (Tylenol)

Toxicity: _ _ → free radical accumulation → hepatocyte necrosis

7
New cards

HPLC

enzyme immunoassay

Acetaminophen (Tylenol)

Detection Methods: _ (reference), _ _ (↓ enzyme activity = ↑ drug concentration)