dissociatives

PCP

synthesized as potential anesthetic agent

did not provide relaxed anesthetic state and had postoperative issues

ketamine

synthesized as a safer alternative to PCP

still used as a valuable anesthetic for certain medical and veterinary procedures

dextromethorphan (DM)

over the counter cough suppressant

nonaddictive substitute for codeine

salvinorin A

most potent naturally occurring hallucinogen

short lasting effects

glutamate

excitatory amino acid neurotransmitter

major transmitter for fast excitatory signaling in the nervous system

glutamine

the precursor to glutamate

glutaminase

enzyme that converts glutamine into glutamate

VGLUT1 2 3

packages glutamate into vesicles

EAAT 1-5

excitatory amino acid transporters in neurons and glia, responsible for inactivation of glutamate via reuptake

eight

number of metabotropic receptors for glutamate

AMPA, NMDA, and Kainate

the three ionotropic receptor for glutamate

each are comprised of 4 subunits