Paramyxovirus

Paramyxovirus

has an affinity for mucous membranes

Enveloped

pleomorphic, budding from plasma membrane

Cytoplasm

Replicates in the

Single negative sense

single standed RNA

hemagglutinating

haemolytic

neuraminidase activities

May exhibit:

respiratory tract

replication occurs primarily in the

synctia and intracytoplasmic, acidophilic inclusions

formation of:

Genus avulavirus (avian)

Newcastle Disease

Genus henipavirus

(reservoir: Pteropus sp. Fruit bats) Zoonotic

Genus henipavirus

Hendra virus (severe respiratory disease in horses)

Genus henipavirus

Nipah virus (in workers handling pigs)- amplifying hosts

Newcastle Disease

Strains:

Velogenic- most pathogenic, high mortality

Mesogenic

Lentogenic- commonly used as vaccine

Newcastle Disease

clinical signs:

torticollis (twisting of neck)

Genus Morbillivirus

Rinderpest- Cattle plague

Genus Morbillivirus

Peste des Petits ruminants (PPR)- Sheep and goat plague, highly contagious

Genus Morbillivirus

Canine distemper

Genus Morbillivirus

Measles (rubeola)- disease of humants that may infect nonhuman primates

Genus Respirovirus

Bovine parainfluenza virus 3- potential role in shipping fever

Genus Rubulavirus

Porcine rubulavirus- blue eye disease

Genus Rubulavirus

Canine parainfluenza virus 5 (previously simian virus 5)

Canine parainfluenza

implicated in the pathogenesis of kennel cough syndrome

Genus Rubulavirus

mumps

human parainfluenza viruses 2 & 4