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nutrients
smaller components
most __________ we eat cannot be used in existing form and must be broken down into ________ _______________ before the body can make use of them
digestive system
essentially a disassembly line
to break down nutrients into a form that can be used by the body
to absorb them so they can be distributed to the tissues
what are the functions of the digestive system
gastroenterology
the study of the digestive tract and the diagnosis and treatment of its disorders
ingestion
secretion
propulsion
digestion
absorption
defecation
what are the 6 stages of digestion?
ingestion
selective intake of food
secretion
endocrine/exocrine glands secrete substances (enzymes, acids, hormones) that aid other digestive processes
propulsion
ingested food is moved from one organ to the next via peristalsis
digestion
mechanical and chemical breakdown of food into a form usable by the body
absorption
uptake of nutrient molecules into the epithelial cells of the digestive tract and then into the blood and lymph
defecation
elimination of feces
mechanical digestion
the physical breakdown of food into smaller particles
cutting and grinding action of teeth
churning action of stomach and small intestine
what are some examples of mechanical digestions in the body?
mechanical digestion
exposes more food surface to the action of digestive enzymes
chemical digestion
a series of hydrolysis reactions that breaks dietary macromolecules into their monomers (residues)
chemical digestion
carried out by digestive enzymes produced by salivary glands, stomach, pancreas, and small intestine
polysaccharides into monosaccharides
proteins into amino acids
fats into monoglycerides and fatty acids
nucleic acids into nucleotides
what are the results of chemical digestion?
digestive tract
gastrointestinal tract
what are the two anatomical subdivisions of the digestive system?
digestive tract
alimentary canal
30 ft long muscular tube extending from mouth to anus
mouth, pharynx, esophagus, stomach, small intestine, and large intestine
what does the digestive tract consist of?
gastrointestinal (GI) tract
makes up the stomach and intestine
teeth, tongue, salivary glands, liver, gallbladder, and pancreas
what are the accessory organs?
epithelium
lamina propria
muscularis mucosae
what are the characteristics of the mucosa (inner most layer)?
submucosa
the layer that surrounds the mucosa
muscularis externa
the layer that surrounds the submucosa
inner circular layer
outer longitudinal layer
what are the two layers of muscularis externa?
areolar tissue
mesothelium
what are the characteristics of the serosa (outer most layer)?
enteric nervous system
a nervous network in the esophagus, stomach, and intestines that regulate digestive tract motility, secretion, and blood flow
enteric nervous system
contains sensory neurons that monitor tension in gut wall and conditions in lumen
submucosal (Meissner) plexus
myenteric (Auerbach) plexus
what are the two networks of neurons that the enteric nervous system is composed of?
submucosal (Meissner) plexus
(in submucosa) controls glandular secretion of mucosa
submucosal (Meissner) plexus
(in submucosa) controls movements of muscularis mucosae
myenteric (Auerbach) plexus
parasympathetic ganglia and nerve fibers between the two layers of the muscularis interna
myenteric (Auerbach) plexus
controls peristalsis and other contractions of muscularis externa
mesenteries
connective tissue sheets that loosely suspend the stomach and intestines from the abdominal wall
motility; secretion
__________ and __________ of the digestive tract are controlled by neural, hormonal, and paracrine mechanisms
short (myenteric) reflexes
long (vagovagal) reflexes
what are the two reflexes of neural control?
short (myenteric) reflexes
stretch or chemical stimulation acts through myenteric plexus
short (myenteric) reflexes
stimulates peristaltic contractions of swallowing
long (vagovagal) reflexes
parasympathetic stimulation of digestive motility and secretion
hormones
chemical messengers secreted into bloodstream and stimulate distant parts of the digestive tract
gastrin and secretion
paracrine secretions
chemical messengers that diffuse through the tissue fluids to stimulate nearby target cells
oral cavity
serves as the start point of the digestive system
ingestion, secretion, chemical and mechanical digestion, and propulsion
what all occurs in the oral cavity?
teeth and tongue and salivary glands
what two accessory organs are located in the oral cavity?
mastication (chewing)
breaks food into smaller pieces to be swallowed and exposes more surface to the action of digestive enzymes
mastication
first step in mechanical digestion
involuntary chewing reflex
during mastication, food stimulates oral receptors that trigger an ___________ __________ _________
teeth
key organs of mechanical digestion
teeth
located in bony sockets found in the maxilla and mandible and held in place by the periodontal ligament
incisors
canines (cuspids)
molars
what are the three types of teeth?
incisors
central teeth that are broad and flat with a narrow crown. specialized for cutting off pieces of food
canines (cuspids)
located on either side of the incisors. have pointed crowns that are specialized for ripping and tearing
molars
posterior and lateral to the canines. contain broad crowns and are specialized for grinding
1. moisten mouth
2. begin starch and fat digestion
3. cleanse teeth
4. inhibit bacterial growth
5. dissolve molecules so they can stimulate the taste buds
6. moisten food and bind it together into bolus to aid in swallowing
what are the functions of saliva?
salivary amylase
lingual lipase
mucus
lysozyme
immunoglobulin A (IgA)
electrolyes
in saliva and salivary glands, what are the solutes with a hypotonic solution of 97% to 99.5% water?
salivary amylase
enzyme that begins starch digestion in the mouth
lingual lipase
enzyme that is activated by stomach acid and digests fat after the food is swallowed
mucus
binds and lubricates the mass of food and aids in swallowing
lysozyme
enzyme that kills bacteria
immunoglobulin A (IgA)
an antibody that inhibits bacterial growth
electrolytes
Na+, K+, Cl-, phosphate, and bicarbonate
6.8 to 7.0
what is the pH for saliva and salivary glands
intrinsic salivary glands
small glands dispersed amid other oral tissues
lingual glands
labial glands
buccal glands
what are the three intrinsic salivary glands?
lingual glands
glands in the tongue; produce lingual lipase
labial glands
glands inside of the lips
buccal glands
glands inside of the cheek
extrinsic salivary glands
three pairs connected to oral cavity by ducts
parotid
submandibular gland
sublingual glands
what are the three extrinsic salivary glands?
parotid
gland located beneath the skin anterior to the earlobe;
mumps is an inflammation and swelling of this gland caused by a virus
submandibular gland
gland located halfway along the body of the mandible; its duct empties at the side of the lingual frenulum, near the lower central incisors
sublingual glands
glands located in the floor of the mouth; has multiple ducts that empty posterior to the papilla of the submandibular duct
1 to 1.5
extrinsic salivary glands secrete about _____ to _____ L of saliva per day
cells of acini
filter water and electrolytes from blood and add amylase, mucin, and lysozyme
salivary nuclei
in the medulla oblongata and pons respond to signals generated by presence of food
salivary nuclei
send signals by way of autonomic fibers in the facial and glossopharyngeal nerves to the glands
parasympathetics
stimulate the glands to produce an abundance of thin, enzyme-rich saliva
sympathetic stimulation
stimulates the glands to produce less, and thicker, saliva with more mucus
(dry or sticky under stress or dehydration)
bolus
mass swallowed as a result of saliva binding food particles into a soft, slippery, easily swallowed mass
pharyngeal constrictors
(superior, middle, and inferior) circular muscles that force food downward during swallowing
esophagus
a straight muscular tube 25 to 30 cm long
pharynx; cardiac orifice; esophageal hiatus
the esophagus extends from ________ to ___________ ___________ of stomach passing through ___________ ________ in diaphragm
lower esophageal sphincter
food pauses at this sphincter
heartburn
burning sensation in the lower esophageal sphincter produced by acid reflex into the esophagus
swallowing (deglutition)
a complex action involving over 22 muscles in the mouth, pharynx, and esophagus
swallowing center
pair of nuclei in medulla oblongata that coordinates swallowing
swallowing center
communicates with muscles of the pharynx and esophagus by way of trigeminal, facial, glossopharyngeal and hypoglossal nerves
voluntary phase
pharyngeal phase
esophageal phase
what three phases occur in swallowing?
peristalsis
wave of muscular contraction that pushes the bolus ahead of it
(entirely involuntary reflex)
1 to 2
4 to 8
liquid reaches the stomach in ______ to ______ seconds;
food bolus in ______ to ______ seconds
stomach
muscular sac in upper left abdominal cavity immediately inferior to the diaphragm
store food
what is the stomach's primary function?
stomach
mechanically breaks up food particles, liquefies the food, and begins chemical digestion of protein and fat
chyme
soupy or pasty mixture of semi digested food in the stomach
gastric pits
depressions in gastric mucosa lined with simple columnar epithelium
cardiac; pyloric; gastric
two or three tubular glands open into the bottom of each gastric pit: the ___________ glands in cardiac region, the ___________ glands in the pyloric region, and the ___________ glands in the rest of the stomach
mucus cells
secrete mucus; predominate in cardiac and pyloric glands
mucous neck cells
in gastric glands, called ________ _______ _______, since they are concentrated at the neck of the gland
regenerative (stem) cells
found in the base of the pit and in the neck of the gland