diseases with oral manifestations

Immune mediated hypersensitivity

What is granulomatous with polyangitis

Strawberry gingivitis

What is the oral presenation of granulomatosis with polyangitis

Deficiency in lysosomal enzyme that prevents breakdown of metabolites leading to free radical formation

What is lysosomal storage disease

Gaucher disease and Mucopolysaccharidosis

What disease are considered lysosomal storage disease

Radiolucency jaw lesions

What oral presenation is seen in Gaucher disease

Large tongue and many impacted teeth

What oral presenation are seen in Mucopolysaccharidosis

Low cortisol and high ACTH

What is adrenal insufficiency (addisons disease)

Hyperpigmented skin and oral mucosa

What is the oral presenation of adrenal insufficiency

Pyostomatitis vegetans

What oral presenation is associated with inflammatory bowel disease

Yellow snail track lesions on soft plate and ventral tongue

What are pyostomatitis vegetans

An type of inflammatory bowl disease that can occur anywhere in the GI tract

What is Crohn’s disease

Apthous ulcer, cobblestone lesion and linear ulcer/fissure in vestibule

What is the oral presenation of Crohn’s disease

Increase in parathyroid hormone due to parathyroid adenoma or chronic renal disease

What is hyper parathyroidism

Radiolucent Brown tumor in the mandible

What oral presentation is associated with hyperparathyroidism

Petechial hemorrhage and ecchymosis, gingival swelling, and TMJ joint pain

What is the oral presentation of vitamin C deficiency

Hypomineralization of teeth and growth impairment

What is the oral presentation of rickets

Prone to bone fractures

What is the oral presentation of osteomalacia

X link autosomal dominant Muation of PHEX genes preventing vitamin D metabolism

What is hereditary hypophosphatemia

Large pulp chambers with pulp horns extending to DEJ, likely early loss of primary teeth due to abscess and adults have many root canals

What is the oral presenation of hereditary hypophosphatemia

Deficiency in alkaline phosphatase due to mutation

What is hypphosphatasia

Large pulp canals and lack of cementum leading to premature tooth loss (first loss Man incisors)

What is the oral presentation of hypophosphastasia

Autosomal dominant NF1 mutation

What is Neurofibromatosis type 1

Multiple neurofibromas of the skin and mucosa

What are the oral presenations of NF1

Peripheral nerve sheath cancer

What can neurofibromas become

Cafe au lait macules, axillary and inguinal freckles, and loach modules in iris

What other symptoms occur in NF1

Autosomal dominant RET mutation

What is multiple endocrine neoplasia type 2 B (MEN2B)

Mucosal neuromas on lips and anterior tongue (first sign)

What are the oral presenations of MEN2B

Medullary thyroid carcinoma and pheochromocytoma (feeling of doom)

What other symptoms occur with MEN2B

Down’s syndrome, edentulous, obesity, amyloidosis, hypothyroidism, NF1 and MEN2B

What can cause macroglossia