Key Antibodies

anti-neurofascin

cell adhesion molecule in both CNS/PNS, so this autoimmune syndrome causes both

anti-MAG

Peripheral demyelinating neuropathy

anti-GM1

Ganglioside ab a/w multifocal motor neuropathy (MMN) or AMAN

Anti-Ri

Causes OMAS

Tumors: breast/gyn cancers (adults), neuroblastoma (peds)

Anti-Yo

Paraneoplastic cerebellar degen

Anti-Hu or ANNA-1

Linked to SCLC —> subacute sensory neuropathy, limbic encephalitis, ataxia, dysautonomia, gastroparesis

anti-amphyiphysin

linked to SPS or an encephalomyelitis

anti-glycine

PERM

anti-ma2

linked to testicular cancer —> limbic/diencephalon/brainstem encephalitis, sleep disorder, hypothalamus dysfunction, vertical gaze palsy

anti-mGluR5

Linked with Hodkins Lymphoma —> limbic/temporal/diencephalon/cerebellar encephalitis

anti-AMPA

Linked with lung/breast/thymic tumors —> Limbic encephalitis (particularly affecting hippocampi) with prominent psych sx

anti-GABA-A

Primarily temporal lobe encephalitis with Severe seizures and cognitive impact

anti-GABA-B

Linked to SCLC —> temporal lobe encephalitis with seizures and cognitive/behavioral sx

anti-CASPR2 or VGKC

Neuromyotonia / Peripheral Nerve Hyper-excitability Syndrome (Isaac syndrome) -myokymia induced by sudden movements, progressive muscle stiffness and painful cramps, delayed muscle relaxation. Sympomatically can tx with CMZ (or other sodium modulators)

Encephalitis with Myokymia and autonomic dysfunction (Morvan syndrome)

anti-IGLON5

Phenotypes include Sleep disorder, Bulbar dysfunction, PSP-like syndrome, Primarily Cognitive, or LMN syndrome (fasiculations and atrophy)

anti-LGI-1

Faciobrachial dystonic seizures, Piloerection, Hyponatremia

anti-GFAP

Astrocytopathy causing subacute meningoencephalomyelitis

MRI with findings of radial/periventricular enhancement

anti-DPPX

CNS hyperexcitability (Hyperkplexia/tremor/sz), neuropsuch + GI manifesations