Codeine (C-II, C-III, C-V)

Codeine (C-II, C-III, C-V) is the generic name for which of the following brand-name drugs? Select all that apply. A. Norco B. Vicodin C. Hysingla ER D. Tylenol with Codeine E. Lorcet

D. Tylenol with Codeine

Which of the following is a common indication for codeine? A. Severe asthma B. Hypertension C. Insomnia D. Pain

D. Pain

Which of the following dosage forms and controlled-substance classifications are available for codeine? Select all that apply. A. Codeine tablets (C-III) B. Codeine/acetaminophen (C-II) C. Codeine solution/acetaminophen (C-V) D. Codeine ER tablets (C-II) E. Codeine transdermal patch (C-IV)

A. Codeine tablets (C-III); B. Codeine/acetaminophen (C-II); C. Codeine solution/acetaminophen (C-V)

Which statement best describes the mechanism of action of codeine? A. Directly blocks opioid receptors to reduce pain B. Inhibits cyclooxygenase enzymes to decrease prostaglandin production C. Acts as a pure kappa-opioid receptor antagonist D. Codeine is 3-methylmorphine whose analgesic activity appears to result from conversion to morphine

D. Codeine is 3-methylmorphine whose analgesic activity appears to result from conversion to morphine

Does codeine require dose adjustment in renal impairment? A. No, dose adjustment is not required B. Yes; reduce the dose by 25% when CrCl is below 60 mL/min C. Yes; CrCl 30–59 mL/min: avoid use or initiate at 50–75% of normal dose; CrCl <30 mL/min: avoid use D. Yes; reduce the dose by 50% only when CrCl is below 15 mL/min

C. Yes; CrCl 30–59 mL/min: avoid use or initiate at 50–75% of normal dose; CrCl <30 mL/min: avoid use

Which of the following are contraindications to codeine therapy? Select all that apply. A. Hypersensitivity B. Bowel obstruction C. Use of MAOI D. Acute or severe asthma E. Mild hypertension F. Hyperlipidemia

A. Hypersensitivity; B. Bowel obstruction; C. Use of MAOI; D. Acute or severe asthma

Which of the following are appropriate counseling points for a patient taking codeine? Select all that apply. A. Take with food to decrease stomach upset and nausea B. Avoid grapefruit or grapefruit juice due to risk of increased codeine toxicity C. If using chronically, use a laxative to help prevent constipation D. Take with grapefruit juice to improve absorption E. Avoid food because it decreases codeine effectiveness

A. Take with food to decrease stomach upset and nausea; B. Avoid grapefruit or grapefruit juice due to risk of increased codeine toxicity; C. If using chronically, use a laxative to help prevent constipation

Which of the following statements regarding boxed warnings for codeine is correct? A. Codeine has no boxed warnings B. Boxed warnings only concern gastrointestinal bleeding C. The primary boxed warning is increased risk of tendon rupture D. Boxed warnings include addiction, respiratory depression, neonatal opioid withdrawal, and concurrent use with benzodiazepines

D. Boxed warnings include addiction, respiratory depression, neonatal opioid withdrawal, and concurrent use with benzodiazepines