q3: summary, platelet shapes, hemostasis overview

promote coagulation (4)

HMWK

Fibrinogen

Factor V

FactorVIII:Vwf

promote aggregation (3)

ADP

Calcium

Platelet factor 4

promote vasoconstriction (2)

Serotonin

Thromboxane A2

promote vascular repair (2)

Platelet derived growth factor

Beta thromboglobulin

other systems affected (3)

Plasminogen

Alpha 2 antiplasmin

C1 esterase inhibitor

substances with dense granules (3)

ADP

Calcium

Serotonin

Contact activation of intrinsic coagulation pathway

HMWK

Converted to fibrin clot formation

Fibrinogen

Cofactor in fibrin clot formation

Factor V

Assist platelet adhesion to subendothelial to provide coagulation surface

FactorVIII:Vwf

Promotes vasoconstriction at injury site

Serotonin

Same as serotonin

Thromboxane A2

Promotes smooth muscle growth for vessel repair

Platelet derived growth factor

Chemotactic for fibroblasts to help in vessel repair

Beta thromboglobulin

Precursor to plasmin, which induces clot lysis

Plasminogen

Plasmin inhibitor; inhibits clot lysis

Alpha 2 antiplasmin

Complement system inhibitor

C1 esterase inhibitor

Inactive, unstimulated, resting and circulating platelet

a. Biconvex and discoid (w/thin and smooth surface)

b. Spherical or round (Rodak's) with pseudopods

c. round up

d. cylindrical and beaded that resembles fragment of megakaryocyte proplatelet

a. Biconvex and discoid (w/thin and smooth surface)

Activated platelet

a. Biconvex and discoid (w/thin and smooth surface)

b. Spherical or round (Rodak's) with pseudopods

c. round up

d. cylindrical and beaded that resembles fragment of megakaryocyte proplatelet

b. Spherical or round (Rodak's) with pseudopods

In EDTA or when at cold/ref temperature and treated with colchicine

a. Biconvex and discoid (w/thin and smooth surface)

b. Spherical or round (Rodak's) with pseudopods

c. round up

d. cylindrical and beaded that resembles fragment of megakaryocyte proplatelet

c. round up

In Citrated blood

a. Biconvex and discoid (w/thin and smooth surface)

b. Spherical or round (Rodak's) with pseudopods

c. round up

d. cylindrical and beaded that resembles fragment of megakaryocyte proplatelet

d. cylindrical and beaded that resembles fragment of megakaryocyte proplatelet

Hemostasis - derived from the Greek word αἱμόστασις (haimóstasis, "styptic drug") which means __

stoppage of blood flow

Process that retains the blood within the vascular system during periods of injury, localizes the reaction involved in the site of injury, and repairs and re-establishes blood flow through the injured vessel.

HEMOSTASIS

The maintenance of circulatory hemostasis is achieved through the process of balancing bleeding (hemorrhage) and clotting (thrombosis).

HEMOSTASIS

Activated by desquamation and small injuries to blood vessels

a. Primary hemostasis

b. Secondary hemostasis

c. Tertiary hemostasis

a. Primary hemostasis

Involves vascular intima and platelets

a. Primary hemostasis

b. Secondary hemostasis

c. Tertiary hemostasis

a. Primary hemostasis

Rapid and short-lived response

a. Primary hemostasis

b. Secondary hemostasis

c. Tertiary hemostasis

a. Primary hemostasis

Main goal is to form a hemostatic plug

a. Primary hemostasis

b. Secondary hemostasis

c. Tertiary hemostasis

a. Primary hemostasis

Activated by large injuries to blood vessels and surrounding tissues

a. Primary hemostasis

b. Secondary hemostasis

c. Tertiary hemostasis

b. Secondary hemostasis

Activated by large injuries to blood vessels and surrounding tissues

a. Primary hemostasis

b. Secondary hemostasis

c. Tertiary hemostasis

b. Secondary hemostasis

Delayed, long term response

a. Primary hemostasis

b. Secondary hemostasis

c. Tertiary hemostasis

b. Secondary hemostasis

Main goal is to form fibrin clot

a. Primary hemostasis

b. Secondary hemostasis

c. Tertiary hemostasis

b. Secondary hemostasis

Delayed, long term response

a. Primary hemostasis

b. Secondary hemostasis

c. Tertiary hemostasis

c. Tertiary hemostasis

Activation of fibrinolysis

a. Primary hemostasis

b. Secondary hemostasis

c. Tertiary hemostasis

c. Tertiary hemostasis

Main goal is to provide clot resolution and dissolution

a. Primary hemostasis

b. Secondary hemostasis

c. Tertiary hemostasis

c. Tertiary hemostasis

Involves the tissues surrounding a vessel

a. Extravascular

b. Vascular

c. Intravascular

a. Extravascular

The ability of the surrounding tissues to aid in hemostasis depends on the ff. factors:

Bulk or amount of the surrounding tissue

The type of tissue surrounding the injured vessel

The tone of surrounding tissue

a. Extravascular

b. Vascular

c. Intravascular

a. Extravascular

Involves the blood vessels in which the blood flows

a. Extravascular

b. Vascular

c. Intravascular

b. Vascular

Inside the blood vessels like platelets and biochemical (procoagulants) in the plasma.

a. Extravascular

b. Vascular

c. Intravascular

c. Intravascular

smallest blood vessel

Capillaries

thickest blood vessel that carries oxygenated blood.

Arteries

w/ valves to prevent backflow of blood. It carries deoxygenated blood

Veins

leads to clot extension and thrombosis

excess hemostasis

leads to poor wound healing and prone to bleeding

inadequate hemostasis