lithium toxicity

what are the clinical features of lithium at a therapeutic dose?

- fine tremor

- dry mouth

- GI disturbance

- increased thirst

- increased urination

- thyroid dysfunction (hypothyroidism)

- nephrotoxicity

what are the clinical features of lithium toxicity?

- coarse tremor

- CNS disturbance (seizures, ataxia, dysarthria)

- polyuria

- cardiac arrhythmias

- visual disturbance

what may precipitate lithium toxicity?

- dehydration

- renal failure

- drugs

which drugs can precipitate lithium toxicity?

- diuretics (thiazides)

- ACEi/ARBs

- NSAIDs

- metronidazole

what is the management of mild-moderate lithium toxicity?

volume resuss with normal saline

what may be needed in severe toxicity with poor renal function?

haemodialysis