Poikilocytosis / RBC, WBC inclusions

Term for increased number of red cells with variation in SHAPE

Poikilocytosis

Lacks central pallor

Spherocyte

Spherocytes may be wrongly reported if one examines which part of the blood film

Feathered edge

Poikilocytosis seen in:

• ABO HDN

• Burns

Spherocytosis

Other name for Stomatocytes

Mouth cell

Poikilocytosis seen in:

• Rh deficiency / null

• Electrolyte imbalance

Stomatocytes

Most common form of stomatocytosis

Dehydrated hereditary stomatocytosis

This is a dehydrated form of a stomatocyte; seen in Dehydrated hereditary stomatocytosis

Xerocyte

RBC with IRREGULARLY spiculated surface

Acanthocyte

Spur cell is AKA

Acanthocyte

Poikilocytosis seen in:

• Abetalipoproteinemia / Bassen-Kornzweig syndrome

Acanthocyte

Poikilocytosis seen in:

• McLeod syndrome

• Pyruvate kinase deficiency

Acanthocyte

Echinocytes are AKA

Burr cell

RBCs with regularly spiculated surface

Burr cell

Poikilocytosis seen in:

• Uremia

Burr cell

Poikilocytosis seen in:

• Thalassemia / Mediterranean Anemia

Elliptocyte

Poikilocytosis seen in:

• Primary myelofibrosis

• Megaloblastic anemia

Dacryocyte

These are pear-shaped or teardrop shaped RBCs

Dacryocyte

Fragmented RBCs

Schistocyte

Poikilocytosis seen in:

• MAHAs (microangiopathic hemolytic anemias)

  • TTP

  • HELLP

  • HUS

  • DIC

Schistocyte

Helmet cells may appear in what group of disorders

MAHAs

Helmet cells are a type of _

Schistocyte

Poikilocytosis seen in:

• DIC

Schistocyte

Related conditions that cause DIC

TOMASA

• Tissue trauma

• Obstetric complications

• Mucus-secreting tumors

• Acute infections

• Snake bites

• Acute promyelocytic leukemia (APL)

Sickle or crescent shaped RBCs

Drepanocyte

Other name for Sickle cell / Menisocyte

Drepanocyte

Reversible form of Drepanocytes; less pronounced projections

Oat-shaped cells

Poikilocytosis seen in:

• LCAT deficiency

Target cell

Leptocyte, Platycyte, Greek helmet cell is AKA

Target cell

target cells appear _ shaped in vivo and on electron microscopy

Bell-shaped

Degmacyte is AKA

Bite cell

Poikilocytosis seen in:

• G6PD deficiency

Bite cell

Most common RBC defect worldwide

G6PD deficiency

Bronze elliptocytes are seen in what disease

Sickle cell anemia

Basophilic stippling content

RNA

Inclusions stained with supravital stains

HHR

• Hemoglobin H

• Heinz bodies

• Reticulocytes

RBC inclusion seen in:

• Saturnism

Basophilic stippling

Saturnism and Plumbism are AKA

Lead poisoning

RBC inclusion seen in:

• Megaloblastic anemia

Basophilic stippling

Well known Iron stain

Prussian blue in Perl’s reagent

Pappenheimer bodies content

Iron

RBC inclusion seen in:

• Sideroblastic anemia

Siderotic granules

Feulgen reaction is a histochemical stain reaction for _

DNA

Difference of Howell-Jolly bodies and Heinz bodies in terms of how they look like

Howell-Jolly: Near middle

Heinz: Edge

RBC inclusion described as threadlike structures that appear as purple-blue loops or rings

Cabot rings

Mitotic spindle remnants are the content of _

Cabot rings

Denatured and precipitated hemoglobin is the content of _

Heinz bodies

RBC inclusion seen in:

• G6PD deficiency

Heinz bodies

RBC inclusion seen in:

• Drug-induced hemolytic anemias (DIHA)

Heinz bodies

Hemoglobin H globin chains

4 beta globin chains

RBC inclusion described as small, multiple, evenly distributed throughout the red cell, granular, greenish-blue bodies

Hemoglobin H

Punched out cell is AKA

Anulocyte

Degmacyte is AKA

Bite cell

Rod/Pencil shaped RBC

Elliptocyte

Menisocyte / Sickle cell is AKA

Drepanocyte

Helmet cell is AKA

Keratocyte

Keratocyte is AKA

Helmet cell

Pinch cell is AKA

Knizocyte

Knizocyte is AKA

Pinch cell

Bronze cell is AKA

Spherocyte

Microcyte size is less than _

<6 um

This is a hexagonal crystal of dense hemoglobin within RBC resembling “Washington monument” or “Gold bar”

Hemoglobin C crystal

This is an RBC with hemoglobin concentrated in the center and around the periphery

Codocyte

This is an RBC with membrane folded over

Folded cell

Folded cells are seen in what disease

Hemoglobin C and Hemoglobin SC

RBC cell seen in PK deficiency

Burr cell

RBC cell seen in Uremia

Burr cell

RBC cell seen in abetalipoproteinemia

Acanthocyte

Degenerating mitochondria are contents found in what RBC inclusion

Basophilic stippling

Type of Basophilic stippling (BS) seen in Pyrimidine-5’-NT deficiency

Coarse BS

Type of Basophilic stippling (BS) seen in lead poisoning

Coarse BS

RBC inclusion seen in unstable hemoglobins

Heinz bodies

RBC inclusions with irregular clusters of small, light to dark granules often near periphery of cell

Pappenheimer bodies

Denatured hemoglobin is the content of what RBC inclusion

Heinz bodies

The Pince-nez nucleus in PH anomaly is seen in Homozygous or Heterozygous?

Heterozygous PH

Neutrophil abnormality associated with mucopolysaccharidosis

Alder-Reilly anomaly

Neutrophil abnormality that resemble toxic granulations

Alder-Reilly anomaly

Reaction of AR anomaly in PAS and Peroxidase

PAS-Positive and Peroxidase-Negative

Disease / Neutrophil abnormality associated with defective giant lysosomal granules

Chediak-Higashi disease

Disease associated with large Dohle body-like inclusions in WBCs

MHA

RBC with membrane folded over

Folded cell

Folded cells are seen in what Hemoglobinopathy

Hb C, Hb SC

RBC seen in PK deficiency

Burr cell

Washington monument RBC

Hb C crystal

RBC inclusion seen in Pyrimidine-5-NT deficiency

Basophilic stippling