Cytokine autoantibodies causing severe infection

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7 Terms

1
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What is meant by an autoimmune phenocopy?

When the body makes autoantibodies targeting interferon gamma, thus blocking type 2 interferon response

2
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Four causes for type I interferon autoantibodies

AIRE -/-

FOXP3 -/-

Thymoma

NFkappaB2 deficiency

3
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Potential reason for some people suffering from Covid more severely?

Already had interferon autoantibodies before infection

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What diseases are interferon autoantibodies related to regarding disease severity?

COVID-19

YF vaccine

MERS

Influenza

West Nile

TBE

Possibly more

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Cytokine autoantibody linked to Mycobacterium

TII IFN

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Cytokine autoantibody related to severe candida

IL-17

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Cytokine autoantibody related to severe Staphylococcus dx

IL-6