NU553 Unit 4 Liver Diseases Advanced Pharmacology and Pharmacotherapeutics Exam 2

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High risk variceal features?

Large varices red wale marks

First line SBP antibiotics?

Third generation cephalosporins

Hold beta blockers if systolic blood pressure below?

90 mmHg

HBV marker for high infectivity?

HBeAg

Major risk after TIPS?

Hepatic encephalopathy

HBV first line drugs?

Entecavir tenofovir

Ascites first line diuretic?

Spironolactone

Hepatorenal syndrome ICU drug?

Norepinephrine

Start portal hypertension therapy when?

Varices identified

Chronic HBV definition?

HBsAg more than 6 months

Octreotide mechanism?

Splanchnic vasoconstriction

HCV cure definition?

No RNA 12 weeks after therapy

SAAG greater than 1.1 meaning?

Portal hypertension

Hemoglobin goal variceal bleed?

7 to 9

First line hepatic encephalopathy?

Lactulose

Alternative to spironolactone?

Amiloride

Avoid tenofovir alafenamide when?

Low kidney function

Hepatorenal syndrome therapy?

Albumin octreotide midodrine

Add on hepatic encephalopathy drug?

Rifaximin

Lactulose goal bowel movements?

2 to 3 daily

Albumin after paracentesis?

6 to 8 grams per liter

DAA risk in HBV?

Reactivation

Add antibiotics variceal bleed?

Prevent SBP

HBV immunity marker?

Anti HBs

Why not use ammonia level?

Poor correlation

Monitor hepatorenal syndrome?

Creatinine urine output

SBP PMN cutoff?

250

SBP common organisms?

Escherichia coli Klebsiella pneumoniae

Portal pressure bleed risk threshold?

12 mmHg

First line portal bleed drug?

Octreotide

Albumin in SBP when?

High creatinine bilirubin BUN

Pan genotypic HCV drugs?

Sofosbuvir velpatasvir glecaprevir pibrentasvir

Avoid protein restriction in HE why?

Malnutrition

SBP prophylaxis drug?

Sulfamethoxazole trimethoprim

Portal hypertension significant threshold?

10 mmHg

Portal hypertension mortality threshold?

16 mmHg

Nadolol clearance?

Renal

Carvedilol advantage?

Alpha 1 blockade

Albumin SBP dosing?

Day 1 and day 3 dosing

When give albumin paracentesis?

More than 5 liters removed

Ascites therapy goals?

Remove fluid prevent recurrence

SVR meaning HCV?

Cure at 12 weeks

Nadolol heart rate target?

55 to 60

Spironolactone furosemide ratio?

100 to 40

AST ALT alcohol pattern?

AST twice ALT

Rifaximin mechanism?

Reduce ammonia bacteria

Octreotide duration?

2 to 5 days

HRS treatment goal?

Bridge to transplant

Stop diuretics creatinine?

Above 2 or doubled

NSBB drugs?

Propranolol nadolol carvedilol

Cirrhosis staging tool?

Child Turcotte Pugh

Mortality score cirrhosis?

MELD sodium

Avoid estrogen with which HCV drug?

Glecaprevir pibrentasvir

Octreotide side effects?

Hyperglycemia QT prolongation

SBP prophylaxis duration?

Indefinite

Lactulose mechanism?

Reduce ammonia via bowel movement