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What are the four primary functions of the spinal cord?
Conduction, neural integration, locomotion, and reflexes
What is meant by conduction in the spinal cord?
Transmission of sensory input to the brain and motor output to effectors
How does the spinal cord contribute to neural integration?
It processes incoming sensory information and generates appropriate motor responses
What role does the spinal cord play in locomotion?
It contains central pattern generators that coordinate repetitive movements like walking
What defines a reflex?
A rapid, automatic response to a stimulus
What is the function of the cervical enlargement?
Supplies nerves to the upper limbs
What is the function of the lumbosacral enlargement?
Supplies nerves to the lower limbs
Where does the spinal cord typically end in adults?
At the level of L1–L2 vertebrae
What is the conus medullaris?
The tapered, cone-shaped end of the spinal cord
What is the cauda equina?
A bundle of spinal nerve roots extending below the spinal cord
What is the function of the filum terminale?
Anchors the spinal cord to the coccyx
What is the lumbar cistern and why is it clinically important?
A CSF-filled space used for lumbar punctures
What are the three layers of the spinal meninges?
Dura mater, arachnoid mater, pia mater
What is located in the epidural space?
Fat and blood vessels
What fills the subarachnoid space?
Cerebrospinal fluid (CSF)
What structures are found in the CNS versus the PNS?
CNS: nuclei and tracts; PNS: ganglia and nerves
What structural components make up white matter?
Myelinated axons
What structural components make up gray matter?
Neuron cell bodies, dendrites, and synapses
What is the function of the central canal?
Circulates cerebrospinal fluid through the spinal cord
What type of neurons are located in the anterior horn?
Somatic motor neurons
What type of information is processed in the posterior horn?
Sensory information
What is the role of the lateral horn?
Contains autonomic motor neurons
What are the three funiculi of spinal white matter?
Posterior, lateral, and anterior funiculi
Where are sensory tracts primarily located in the spinal cord?
Posterior and lateral funiculi
Where are motor tracts primarily located in the spinal cord?
Anterior and lateral funiculi
What is the function of ascending tracts?
Transmit sensory information to the brain
What is the function of descending tracts?
Transmit motor commands from the brain
What does decussation mean in neural pathways?
Crossing from one side of the body to the other
What is the difference between contralateral and ipsilateral pathways?
Contralateral cross sides; ipsilateral remain on the same side
What type of sensory information is transmitted by the posterior column pathway?
Fine touch, vibration, and proprioception
Where do second-order neurons of the posterior column pathway cross?
In the medulla
Where is sensory information from this pathway ultimately processed?
Primary somatosensory cortex
What type of sensory information is transmitted by the spinothalamic pathway?
Pain, temperature, and crude touch
Where does the spinothalamic pathway decussate?
In the spinal cord
Where do upper motor neurons originate?
In the cerebral cortex
Where are lower motor neuron cell bodies located?
In the anterior horn of the spinal cord
What are the five components of a reflex arc?
Receptor, sensory neuron, integration center, motor neuron, effector
What is an example of a stretch reflex?
Patellar (knee-jerk) reflex
What is the purpose of the flexor (withdrawal) reflex?
To remove a body part from a painful stimulus
What is the function of the crossed extension reflex?
Maintains balance during withdrawal
Where is a lumbar puncture performed and why?
In the lumbar cistern to collect CSF safely
What are common symptoms of meningitis?
Fever, stiff neck, headache
What causes shingles and where does it originate?
Varicella-zoster virus in dorsal root ganglia
What is a dermatome?
An area of skin supplied by a single spinal nerve
Why are dermatomes clinically important?
They help identify nerve damage or compression
How many pairs of spinal nerves are there?
31 pairs
How many cervical spinal nerves exist?
8 pairs
How many thoracic spinal nerves exist?
12 pairs
How many lumbar spinal nerves exist?
5 pairs
How many sacral spinal nerves exist?
5 pairs
What structures are controlled by the autonomic nervous system?
Glands, smooth muscle, and cardiac muscle
Is the autonomic nervous system under voluntary or involuntary control?
Involuntary
How does the ANS pathway differ from the somatic motor pathway?
It uses a two-neuron chain
Where does the preganglionic neuron originate and what does it release?
In the CNS; releases acetylcholine
What is the role of the postganglionic neuron?
It transmits signals from ganglion to target tissue
What are the two main divisions of the ANS?
Sympathetic and parasympathetic
What is the function of the sympathetic division?
Prepares the body for stress (“fight or flight”)
What is the function of the parasympathetic division?
Promotes rest and digestion
Where does the sympathetic division originate?
Thoracolumbar region (T1–L2)
What is the general length pattern of sympathetic fibers?
Short preganglionic, long postganglionic
Where are sympathetic ganglia located?
Near the spinal cord
What neurotransmitter is most commonly released by sympathetic postganglionic neurons?
Norepinephrine
Where does the parasympathetic division originate?
Craniosacral regions
What is the fiber length pattern of parasympathetic neurons?
Long preganglionic, short postganglionic
What neurotransmitter is released by parasympathetic postganglionic neurons?
Acetylcholine
Which neurotransmitters bind to adrenergic receptors?
Norepinephrine and epinephrine
Which neurotransmitter binds to cholinergic receptors?
Acetylcholine
Where are nicotinic receptors found?
On postganglionic neurons in ganglia
Where are muscarinic receptors found?
On target organs
How does sympathetic stimulation affect the heart?
Increases heart rate and force
How does sympathetic stimulation affect the lungs?
Causes bronchodilation
How does sympathetic stimulation affect digestion?
Inhibits digestive activity
How does parasympathetic stimulation affect digestion?
Enhances digestive activity
What are white rami communicantes?
Preganglionic sympathetic fibers
What are gray rami communicantes?
Postganglionic sympathetic fibers
What are sympathetic chain (paravertebral) ganglia?
Ganglia running alongside the spinal cord
What are collateral ganglia?
Ganglia located near target organs
What is the function of the enteric nervous system?
Controls gastrointestinal activity
What makes the enteric system unique?
It can function independently of the CNS
What is the effect of alpha-1 receptor activation?
Vasoconstriction
What is the effect of beta-1 receptor activation?
Increases heart activity
What is the effect of beta-2 receptor activation?
Bronchodilation
How do beta blockers affect the body?
Reduce heart rate
How do alpha blockers affect blood vessels?
Cause relaxation (vasodilation)
What does dual innervation mean?
Organs receive input from both ANS divisions
What are the three major regions of the brain?
Cerebrum, cerebellum, brainstem
What does the term rostral refer to in the brain?
Toward the front (forehead)
What does the term caudal refer to?
Toward the spinal cord
What is the largest part of the brain?
Cerebrum
What is the function of the precentral gyrus?
Voluntary motor control
What is the function of the postcentral gyrus?
Somatic sensory processing
Why are gyri important?
They increase surface area for more neurons
What functions are associated with the frontal lobe?
Decision-making, motor control
What functions are associated with the parietal lobe?
Sensory processing
What functions are associated with the temporal lobe?
Hearing and memory
What functions are associated with the occipital lobe?
Vision
What structures make up the brainstem?
Midbrain, pons, medulla
What vital functions are controlled by the medulla oblongata?
Heart rate, breathing, blood pressure
What is the role of the pons?
Breathing regulation and signal relay
What is the role of the midbrain?
Reflexes related to vision and hearing