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The Centers for Disease Control and Prevention (CDC) recommends that universal precautions be followed when encountering:
C. All body fluid specimens
B. Patients who are infected with blood-borne pathogens
A. Specimens containing visible blood
D. Specimens that may produce aerosols
A. Specimens containing visible blood
A urine specimen received in the laboratory is leaking in a transport bag. What is the next course of action?
B. It should be rejected.
C. It should be processed with no special handling.
D. It should be poured into a clean container. A. It should be relabeled.
B. It should be rejected.
Which is not a disadvantage of performing the manual microscopic analysis?
D. Time saving
A. Centrifugation
B. Standardization
C. Variability
D. Time saving
Plexiglas shields are used in the laboratory when urine tube specimens are being:
B. Uncapped for analysis
D. Observed for color characteristics
A. Sorted according to laboratory
C. Centrifuged for analysis
B. Uncapped for analysis
What does a fully automated analyzer provide that a semiautomated analyzer does not?
C. Minimal specimen handling
D. Ease of use
A. Specific gravity
B. Chemical analysis
C. Minimal specimen handling
You arrive to work in the clinical laboratory with a small cut on your hand. Your supervisor removes you from specimen collection (phlebotomy) duties for the day, citing chain of infection protocols. Why is your supervisor concerned about the cut on your hand?
B. Because you are going to have to wear a bandage all day long.
C. Because you have a point of entry that could expose you to infectious agents.
A. Because you will not have the mobility in your hand to properly collect blood.
D. Because you are going to be an active transmitter of infection onto general surfaces.
C. Because you have a point of entry that could expose you to infectious agents
The principle of reflectance photometry is:
D. A light-emitting diode for a specific wavelength to measure color
C. Enzymes utilizing chemical pads to generate light to measure color
B. Electrical current that causes a change in electrical resistance to measure color
A. Laser light that causes a deflection of the light beam to measure color
D. A light-emitting diode for a specific wavelength to measure color
Proper hand washing includes all of the following procedures except:
D. Using a paper towel to turn water faucet on
B. Using warm water
C. Rinsing hands in a downward position
A. Rubbing to create a lather
D. Using a paper towel to turn on the water faucet
Centrifuging an uncapped tube of urine is most likely to produce a/an:
C. Unbalancing
D. Aerosol
B. Broken tube
A. Electrical shock
D. Aerosol
Which of the following urine elements if flagged by automated microscopy would need to be confirmed by a manual examination?
B. White blood cells
C. Crystals
A. Red blood cells
D. Bacteria
C. crystals
John White donates one of his two healthy kidneys to his twin brother. His glomerular filtration rate can be expected to:
A. Decrease by 50%
D. Remain within a normal range
C. Decrease gradually over 1 year
B. Increase by 50%
D. Remain within a normal range
To enhance the excretion of hydrogen ions, ammonia is produced by the cells of the:
C. Distal convoluted tubule
B. Loop of Henle
D. Collecting duct
A. Proximal convoluted tubule
A. Proximal convoluted tubule
Kidneys with impaired production of ammonia will consistently produce urine with a:
D. Low volume
A. High pH
C. Low pH
B. High volume
A. High pH
All of the following are endogenous clearance test substances except:
D. Beta2 microglobulin
A. Urea
B. Creatinine
C. Inulin
C. Inulin
If a substance is completely filtered by the glomerulus and then completely reabsorbed by the tubules, the clearance of that substance will be:
A. Falsely decreased
B. Falsely increased
C. Normal
D. Zero
D. Zero
The renal function that is most frequently the first affected by early renal disease is:
C. Tubular reabsorption
A. Renal blood flow
B. Glomerular filtration
D. Tubular secretion
C. Tubular reabsorption
For accurate evaluation of renal tubular concentrating ability, patient preparation should include:
D. Abstaining from all medications
A. Fasting
B. Fluid deprivation
C. Increased hydration
B. Fluid deprivation
Calculate the creatinine clearance for a patient of average size from the following data: Urine volume: 720 mL for 12 hours Urine creatinine: 120 mg/dL Serum creatinine: 1.5 mg/dL
C. 100 mL/min
A. 60 mL/min
B. 80 mL/min
D. 120 mL/min
B. 80 mL/min
Measurement of urine osmolality is a more accurate measure of renal concentrating ability than specific gravity because
A. Osmolality is measured by instrumentation
D. Specific gravity measures only urea and glucose molecules
C. Osmolality is influenced equally by small and large molecules
B. Specific gravity is not influenced by urea and glucose molecules
C. Osmolality is influenced equally by small and large molecules
Substances that can interfere with serum osmolality readings include all of the following except:
A. Lipids
D. Sodium
B. Lactic acid
C. Ethanol
D. Sodium
What is the clinical importance of bilirubin in urine?
Early sign of liver disease
Sign of renal tubular damage
Marker of dehydration
Sign of UTI
Early sign of liver disease
Which urine constituent is measured by the pseudoperoxidase activity of hemoglobin?
Blood
Glucose Blood
Bilirubin
Nitrite
Blood
If specific gravity is consistently around 1.010, what condition does this suggest?
Dehydration
Loss of kidney concentrating ability
Normal hydration
Diabetes mellitus
Loss of kidney concentrating ability
A positive Clinitest but negative glucose oxidase strip result suggests:
High vitamin C interference
Bacterial contamination
Presence of non-glucose reducing sugars (e.g., galactose)
False positive glucose oxidase test
Presence of non-glucose reducing sugars (e.g., galactose)
Which confirmatory test is used for bilirubin?
Acetest
Ictotest
Clinitest
SSA test
Ictotest
Which reagent strip test uses the “protein error of indicators” principle?
Protein
Glucose
Specific gravity
Bilirubin
Protein
Which protein is most clinically significant in proteinuria?
Myoglobin
Bence Jones protein
Globulins
Albumin
Albumin
Which strip test can show a “speckled” color pattern due to intact red blood cells?
Blood strip test.
Which ketone body is present in the highest concentration during ketosis?
β-hydroxybutyrate
Acetoacetic acid
All equal
Acetone
β-hydroxybutyrate
What color change indicates a positive nitrite test on reagent strips?
Blue to violet
Yellow to green
White to pink
Orange to brown
White to pink
A diabetic patient has glycosuria but a normal blood glucose. What condition might this indicate?
Gestational diabetes
Fanconi syndrome
Renal glycosuria
Cystitis
Renal glycosuria
A patient’s dipstick shows trace protein but the SSA test is strongly positive. What does this suggest?
False negative dipstick
Improper storage of strips
Presence of non-albumin proteins
False positive SSA test
Presence of non-albumin proteins.
What is the main reagent used in ketone reagent strip testing?
Diazonium salt
Sodium nitroprusside
Bromthymol blue
Ehrlich's reagent
Sodium nitroprusside
A sample tests positive for bilirubin on the strip, but negative with Ictotest. What does this indicate?
True bilirubinuria
Both tests invalid
False positive dipstick (interference)
False negative Ictotest
False positive dipstick (interference)
A patient has high urine urobilinogen but negative bilirubin. What is the most likely condition?
Bile duct obstruction
Hepatitis
Renal tubular damage
Hemolytic disorder
Hemolytic disorder
What is the normal pH range of urine?
5.5-10.0
6.5-9.5
3.0-6.0
4.5-8.0
4.5-8.0
A child’s urine tests positive on Clinitest but negative on dipstick glucose. What condition should be suspected?
Fanconi syndrome
Multiple myeloma
Galactosemia
Diabetes mellitus
Galactosemia
The glucose oxidase strip test is specific for which substance?
All reducing sugars
Fructose
Glucose
Galactose
Glucose
A urine strip shows positive leukocyte esterase and nitrite. What condition is most likely?
Hemolysis
UTI
Renal glycosuria
Ketoacidosis
UTI
A urine specimen has a pH of 9.0 and high bacteria growth. What is the most likely cause?
Glomerular damage
Improper preservation of the sample
False negative protein result
Alkaline diet only
Improper preservation of the sample