L2 | Pathologists

William Osler

He was known to be a key figure in the development of internal medicine

Rubor (redness), tumor (swelling), calor (heat), dolor (pain), and functio laesa (loss of function)

What are the four cardinal signs of inflammation?

William Osler

He was known to be a key figure in the development of internal medicine

Rubor (redness), tumor (swelling), calor (heat), dolor (pain), and functio laesa (loss of function)

What are the four cardinal signs of inflammation?

Cornelius Celsus

He developed the four cardinal signs of inflammation

Anton van Leeuwenhoek

the father of microscopy and developed a histological stain for muscle tissue

Saffron Stain

the histological stain for muscle tissue developed by Leeuwenhoek

Marcello Malpighi

known as the father of histology

Capillaries of the skin

what specific area of the body did Malpighi study

Clinicopathologic correlation (CPC)

What did Morgagni study to understand the relationship between clinical findings and pathological changes

Giovanni Morgagni

He studied the cause, lesions, symptoms, and outcome of diseases

Chimney soot

What substance did Pott discover to be carcinogenic?

Pervical Pott

Known to discover factors that cause cancer

Pathologic anatomy

What field of medicine did John Hunter contribute to by explaining the structural changes that can lead to disease?

Richard Bright (Bright's disease)

Was first to described GLOMERULONEPHRITIS

Thomas Addison (Addison's disease)

Discovered adrenal insufficiency

Thomas Hodgkin (Hodgkin's Disease)

Discovered the disease that involves enlargement of the liver and spleen

Autopsy

What technique is Carl von Rokitansky known for developing?

Syphilis

What disease did Paul Ehrlich discover a treatment for?

Penicillin G

treatment for Syphilis that Ehrlich discovered

Mycobacterium tuberculosis (Koch's bacillus); methylene blue stain

What microorganism is associated with Robert Koch's research, and what stain did he use to identify it?

Giemsa stain; May-Grunwald-Giemsa (MGG) [type of Romanowsky-Giemsa]

What stain is used to study the morphology of cells? Who developed this?

Christian Gram

Who introduced the stain for bacteria?

Eosin & methylene blue; platelets

What stain is used for peripheral blood films, and what specific structures does it highlight?

Dark violet structures

Describe the appearance of platelets on a PBS film using Giemsa stain

Cytochemistry and histochemistry

What fields of study did Robert Feulgen contribute to with his work?

Etiology of embolism

What aspect of disease did Rudolf Virchow investigate?

Frozen section or cryostat

What technique did Julius Cohnheim introduce for rapid tissue processing?

Electron microscope

What invention is attributed to Ruska and Lorries?

Pap smear; diagnosis of cervical cancer

What is Papanicolaou known for developing? What is its primary purpose?

George Papanicolaou

Known as the "Father of Exfoliative Cytology"