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Oxygen - Classification
Atmospheric Gas
Oxygen - Mechanism of Action
Aerobic metabolism - oxidation of glucose to form ATP
Oxygen - Indications
Hypoxia
Shock
Ischemic chest pain
Respiratory Insufficiency
Comfort Measures
Oxygen - Contraindications
COPD Patients (Use caution)
Oxygen - Side effects
Dried mucous membranes
Oxygen - Dosage
Adult & Pediatric: Pt specific (target 94-99%)
Delivery method: NC - 1-6lpm, NRBM - 10-15lpm, BVM - 12-25lpm
Epinephrine (1:1000) - Classification
Sympathomimetic
Sympathetic agonist
Epinephrine (1:1000) - Mechanism of Action
Positive stimulation of Alpha and Beta adrenergic receptors
Antagonizes histamine effects
Epinephrine (1:1000) - Indications
Anaphylaxis (severe allergic reaction)
Asthma
Epinephrine (1:1000) - Contraindications
None in the emergency setting
Epinephrine (1:1000) - Side Effects
Tachycardia
Hypertension
Angina
Headache
Nausea/Vomiting
Epinephrine (1:1000) - Dosage
Adult: 0.3-0.5mg IM/SQ (Preferred IM)
Pediatric: 0.01mg/kg IM/SQ (Preferred IM)
Albuterol - Classification
Bronchodilator
Sympathomimetic selective B-2
Albuterol - Mechanism of Action
Bronchodilation via stimulation of adrenergic receptor sites
Albuterol - Indications
Bronchospasms
Asthma
COPD
Wheezing
Albuterol - Contraindications
Unstable tachycardia
Albuterol - Side effects
Palpitations
Tachycardia
Nervousness
Albuterol - Dosage
Adult & Pediatric: 2.5mg diluted to 3ml with NS nebulized
Oral Glucose - Classification
Hyperglycemic
Carbohydrate
Oral Glucose - Mechanism of Action
Absorption into the GI tract providing prompt increase in circulating blood sugar
Oral Glucose - Indications
Conscious hypoglycemia
Oral Glucose - Contraindications
Hyperglycemia
Inability to protect airway
Oral Glucose - Side effects
Nausea/Vomiting
Oral Glucose - Dosage
Adult & Pediatric: 15gm PO (Max 30gm)
Naloxone - Classification
Opioid Antagonist
Naloxone - Mechanism of Action
Competes at the opiate receptor sites to antagonize the effects of both natural and synthetic opiates
Naloxone - Indication
Opioid overdose
Unconscious/Unknown
Naloxone - Contraindication
None in the emergency setting
Naloxone - Side effects
Withdrawal syndrome
Tachycardia
Seizures
Pulmonary Edema
Naloxone - Dosage
Adult: 0.4-2mg q5-10 mins IN/IV/IM/IO
Pediatric: 0.1mg/kg (max 2mg) q5-10 mins IN/IV/IM/IO
Aspirin - Classification
Platelet anti-aggregator
Aspirin - Mechanism of Action
Blocks platelet aggregation by blocking the synthesis of thromboxane A2
Aspirin - Indications
Symptoms suggestive of myocardial ischemia (ACS)
Aspirin - Contraindications
Active ulcer disease (relative)
Asthma (relative)
Bleeding disorders (relative)
Aspirin - Side effects
Exacerbation of bleeding disorder
Aspirin - Dosage
162-325mg PO
Nitroglycerin - Classification
Vasodilator
Antianginal
Nitroglycerin - Mechanism of Action
Relaxes vascular smooth muscle decreasing preload and afterload on the heart
Nitroglycerin - Indications
Chest pain (ACS)
Pulmonary edema
Hypertensive crisis
Nitroglycerin - Contraindications
Hypotension
Recent ED medication usage
Nitroglycerin - Side effects
Hypotension
Headache
Tachycardia
Syncope
Nitroglycerin - Dosage
Adult: 0.4mg SL q3-5 mins (max 3 doses)
D50w/D25w/D10w - Classification
Antihypoglycemic
Carbohydrate
D50w/D25w/D10w - Action
Brief osmotic diuretic
Sends simple blood sugar to hypoglycemic brain tissue
D50w/D25w/D10w - Indications
Hypoglycemia
AMS (blood sugar unavailable)
Coma of unknown origin
D50w/D25w/D10w - Contraindications
Intracranial hemorrhage
BG >60mg/dL
D50w/D25w/D10w - Side effects
Worsening of brain injury (if present)
D50w/D25w/D10w - Dosage
Adult (50% solution): 12.5-25gm slow IV push (large bore catheter)
Pediatric (25% solution): 0.5-1gm/kg
Glucagon - Classification
Hormone
Glucagon - Action
Increases breakdown of glycogen to glucose
Decreases the synthesis of glycogen from glucose
Positive chronotropic and inotropic agent
Glucagon - Indications
Hypoglycemia (absolutely unable to start an IV or admin oral glucose)
Beta blocker overdose
Glucagon - Contraindications
None
Glucagon - Side effects
Hyperglycemia
Hypokalemia
Glucagon - Dosage
Adult: 0.5-1mg q20 mins IM/IV
Opiate Analgesics - Classification
Opioid Analgesic
Narcotic
Schedule II drug
Opiate Analgesics - Action
Central nervous system depressant that acts on the opiate receptors in the brain
Vasodilator (analgesic specific)
Opiate Analgesics - Indication
Pain indicative of ACS (analgesic specific)
Pulmonary edema
Pain protocol
Opiate Analgesics - Contraindication
Right ventricular infarct (RVI)
Opiate Analgesics - Side effects
Hypotension
Respiratory depression
Decreased LOC
Opiate Analgesics - Dosage
Adult: Morphine: 2-10mg IV/IM/IO
Adult: Fentanyl: 1mcg/kg (max 100mcg) IV/IM/IO/IN
Pediatric: Consult local protocol
Ondansetron - Classification
SSRA (Selective Serotonin Receptor Antagonist)
Antiemetic
Ondansetron - Action
Blocks serotonin receptor sites in the CNS at the CTZ
Ondansetron - Indications
Nausea and Vomiting
Prophylaxis for opiate administration
Ondansetron - Contraindications
Known prolonged QT syndrome
Ondansetron - Side effects
Headache
Dizziness
Ondansetron - Dosage
Adult: 4mg slow IV push
Pediatric: 0.1mg/kg slow IV push (max 4mg)
Epinephrine (1:10,000) - Classification
Catecholamine
Sympathetic agonist
Epinephrine (1:10,000) - Action
Positive stimulation of alpha and beta adrenergic receptors
Epinephrine (1:10,000) - Indications
Dead
Epinephrine (1:10,000) - Contraindications
None in the emergency setting
Epinephrine (1:10,000) - Side effects
Increase myocardial O2 demand
Tachy-dysrhythmias
Epinephrine (1:10,000) - Dosage
Adult: 1mg IV/IO q3-5 mins
Pediatric: 0.01mg/kg (max 1mg) IV/IO