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GnRH Biochemical Classification
Neuropeptide
LH Biochemical Classification
Glycoprotein
FSH Biochemical Classification
Glycoprotein
Oxytocin Biochemical Classification
Neuroprotein
Estradiol Biochemical Classification
Steroid
Progesterone Biochemical Classification
Steroid
Testosterone Biochemical Classification
Steroid
Inhibin Biochemical Classification
Glycoprotein
PGF2a Biochemical Classification
Prostaglandin
GnRH Source
Hypothalamic surge and tonic centers
LH Source
Anterior lobe
FSH Source
Anterior lobe
Oxytocin Source
Synthesized in the hypothalamus, stored in the posterior lobe of the pituitary; synthesized by the corpus luteum
Estradiol Source
Granulosal cells of the follicle, placenta, Sertoli cells of testis
Progesterone Source
Corpus luteum and placenta
Testosterone source
Interstitial cells of leydig, cells of the theca interna in females
Inhibin source
Granulosal cells (female) and Sertoli cells (male)
PGF2a Source
Uterine endometrium, vesicular glands
GnRH Target Tissue
Male and Female: anterior lobe of the pituitary
GnRH primary action
Male and Female: Release of FSH and LH from anterior lobe of pituitary
LH target tissue
male: Testis (Sertoli cells), female: Ovary (granulosa cells)
LH primary action
male: sertoli cells function, female: Follicular development and estradiol synthesis
Oxytocin female target tissue
Myometrium and endometrium of uterus, myoepithelial cells of mammary gland
Oxytocin female primary function
Uterine motility, promotes uterine PGF2⍶ synthesis, milk ejection
Estradiol female target tissue
Uterine endometrium, mammary gland, myometrium, hypothalamus
Estradiol female primary function
Endometrial secretion, inhibits GnRH release, inhibits reproductive behavior, promotes maintenance of pregnancy
Testosterone male target tissue
male: Accessory sex glands, tunica dartos of scrotum, seminiferous epithelium, skeletal muscle
Testosterone male primary action
Anabolic growth, promotes spermatogenesis, promotes secrtion of accessory sex glands
Testosterone female primary action
Substrate for estradiol synthesis, abnormal masculinizataion
Inhibin target tissue
anterior lobe of pituitary
Inhibin primary function
inhibits FSH secretion
PGF2a female target tissue
Corpus luteum, uterine myometrium, ovulatory follicles
PGF2a female primary action
Luteolysis, promotes uterine tone and contraction, ovulation