Derm Lecture 4

What is the most deadly skin cancer?

Malignant Melanoma

What are the 6 categories of malignant melanoma and their associations?

Superficial spreading melanoma (MC) - intermittent sun exposure

Lentigo melanoma- photodamage + elderly

Nodular melanoma

Acral-lentiginous melanoma- dark/irreg. palms, soles, nails

Ocular melanoma

Mucosal melanoma

Clinical manifestation of Superficial spreading Melanoma

Rapid radial growth

MC on intermittent sun exposed areas

Acral Litigious clinical manifestation

Dark, irreg shaped lesions

MC on palms, soles, nailbeds

common in Asians and Blacks

Which skin cancer presents with a Pagetoid growth pattern histologically in which abnormal melanocytes spread into upper layers of the dermis?

Malignant Melanoma

What are the stages of Breslow thickness?

Stage 1: less than 1mm

Stage 2: 1-2mm

Stage 3: 2.1-4 mm

Stage 4: greater than 4 mm

Management of Malignant Melanoma

Excisional biopsy clean margins

Chemotherapy/Immunotherapy

Radiation

Serial monitoring

Sentinel lymph node biopsy if lesion greater than 8mm

What is the second most common skin cancer?

Squamous Cell Carcinoma

A biopsy under microscope reveals Nodules with laminated centers called Keratin Pearls. What condition is this indicative of?

Squamous cell carcinoma