In the resting state, a neuron has a negative charge (negative ions in the cell and positive ions surrounding it). The cell membrane is selectively permeable to prevent them from mixing.
Reaction begins when terminal buttons of neuron A are stimulated and release neurotransmitters into the synapse. These neurotransmitters fit into receptor sites of neuron B.
If enough neurotransmitters are received (threshold), the membrane of neuron B becomes permeable and positive ions rush through the cell (action potential). When the charge reaches the terminal buttons of neuron B, the buttons release their neurotransmitters into the synapse.
The process may begin again if enough neurotransmitters are received by that next cell to pass the threshold.