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Use HIGH SENSITIVITY when...
Missing a real case is dangerous (e.g. disease screening)
False positives are acceptable — they lead to more tests
Use HIGH SPECIFICITY when...
A false alarm causes harm (e.g. selecting patients for risky surgery)
False positives are NOT acceptable — they cause unnecessary harm
Bootstrapping
Sample WITH REPLACEMENT to build training set
All unselected data (~36.8%) becomes test set
Repeat many times and average results
Slightly pessimistic (conservative) estimate
Cross-Validation (k-fold)
Split data into K equal folds
Train on K-1 folds, test on 1 fold
Rotate K times, average all test results
Unbiased estimate — every point tested once
Both methods
Estimate the TRUE error rate, NEVER evaluate on training data — the model already 'knows' it!
Predicted Positive and Actual Positive equal...
True Positive (TP)
Predicted Negative and Actual Positive equal..
False Negative (FN)
Predicted Positive and Actual Negative equal...
False Positive (FP)
Predicted Negative and Actual Negative equal...
True Negative (TN)