Lithium Toxicity

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6 Terms

1
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Therapeutic range

0.5-1.2 meq/L

2
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Risk For Toxicity

  • Toxic range >1.5 meq/L

  • ↑­r/f toxicity if renal disease, elderly, GI bug (N/V/D), dehydration, overdose, loop diuretics

3
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S/s of litium toxicity: Early

  1. Dry mouth

  2. Wt. gain

  3. Thirst

  4. ↓Coordination

  5. ↑­Confusion

  6. Sedation

  7. N/V/D

  8. Tremors

  9. Abd pain

4
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S/s of litium toxicity: Advanced toxicity

  • Seizures

  • Stupor

  • Dilute urine

  • Tinnitus

  • Jerky movement

5
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Tx for toxicity

  • D/c lithium

  • Mannitol or urea

6
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Toxicity Prevention

  • Blood test q 1-2 weeks when starting

  • Do not limit sodium or water intake

  • 1-3 L/day water

  • No diuretics (coffee, furosemide, anticholinergics)

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