M3L4 - Traditional knowledge for drug discovery

Chemistry gap

This describes the absence of comprehensive chemical analyses on natural product sources and indigenous medicinal plants

Prostratin

This is an antiviral isolated from the bark of the Mamala tree, exposes hidden HIV virus to other drugs whilst preventing cell death of HIV-infected human cells

Methylglyoxal

This is an antibacterial compound found in Mānuka honey, allows it to be used in wound care, gels, and dressings

Mamala leaf

This is a plant material used traditionally for treating sores, cuts, wounds, abdominal swelling, and convulsions

Astragalin

This is a flavanoid phenylpropanoid compound isolated from the Mamala leaf, reported bioactivities include anti-inflammatory, antioxidant, and antimicrobial activities

Methylated geraniin derivative

This is a compound isolated from the dereplication route study of the Mamala leaf, previously undiscovered

Cinnamoyl-piperidine

This is a piperidine-type amide derivative isolated from Fuemanogi, reports anti-inflammatory and analgesic activity

Diayangambin derivative

This is a chemically known compound, discovered new naturally in Fuemanogi and may have anticonvulsant properties

Chemotype

This is a chemically unique natural product form from the same plant species

Ilepcimide

This is a demethoxylated analogue of major Fuemanogi constituent (Z-267), used as an anticonvulsant in traditional Chinese medicine

E-113

This is a major CT-1 constituent with reported antibacterial activity

Z-267

This is a major CT-1 constituent with reported anticonvulsant activity