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Flashcards about Thermoregulation and Fever
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Human thermoregulation
Achieved through precise balancing of heat production, heat conservation, and heat loss.
Average optimal range of body temperature
Considered to be 37°C (35.8°C – 38.2°C range).
Optimal temperature
Required for enzyme reactions within the body that are vital for survival.
Thermoregulation is mediated
Primarily by the hypothalamus, the endocrine system and the sympathetic nervous system.
Peripheral thermoreceptors
In the skin and central thermoreceptors in the hypothalamus and other locations provide information about skin and core temperatures.
If the body temperatures is low or high
The hypothalamus responds by triggering heat production, heat conservation, or heat loss mechanisms.
Hypothermia
Core temperature less than 36°C (96.8°F). Can be classified as mild, moderate, or severe.
Mild Hypothermia
Core body temperature of 34°C to 35°C (93.2°F to 95°F).
Moderate Hypothermia
Core body temperature of 30°C to 34°C (86°F to 93.2°F).
Severe Hypothermia
Core body temperature less than 30°C (86°F).
Heat promoting mechanisms
Constriction of cutaneous blood vessels, increase in metabolic rate, shivering, enhanced release of thyroxine, behavioral modifications.
Behavioral modifications for heat promotion
Putting on warmer clothing, drinking hot fluids, changing posture to reduce exposed body surface, increasing physical activity.
Hyperthermia
The state of elevated body temperature.
Fever
A systemic response to invading microorganisms; commonly occurs during infection and inflammation.
Post-operative fever
Mild temperature elevation may be transient in nature and may arise from the body's response to tissue injury.
Heat loss mechanisms
Dilation of cutaneous blood vessels, enhanced sweating, behavioural modifications.
Behavioral modifications for heat loss
Reducing activity, seeking a cooler environment, using a device to increase convection, wearing light-colored, loose clothing.
Exogenous pyrogens
Endotoxins produced by pathogens.
Endogenous pyrogens
Act on the body’s thermostat- hypothalamus. Release of prostaglandins.
Hypothalamic thermoregulatory center accomplishes heat production by
Inducing shivering and heat conservation through vasoconstriction.
Benefits of Fever
Kills many microorganisms, decreases serum levels of iron, zinc, and copper, prevents viral replication, improves immune response.
Additional benefits of fever
Enhances phagocytosis, increases production of antiviral interferons.
Risks of Fever
Brain damage if sustained temperature > 41°C, death > 43°C, febrile seizures (>39°C).