DNA-Binding Domains and Motifs

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DNA-Binding Domains and Motifs

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1.      Specificity of gene regulation is governed by the molecular architecture of TFs.

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1.      Dna binding domain

1.      Dna binding domain topics

examples

function

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tf motifs

tf motifs topics

func

def

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Example drosophilia homeodomain protein msx1

Example drosophilia homeodomain protein msx1 topics

func

mech

what does every tf have

DNA-binding domain (DBD),

dbd examples

zinc finger, homeodomain, or helix-loop-helix,

dbd func

recognizes highly specific regions of the genome.

transcription factor motifs function

mediated dbd recognition of highly specific regions of genome

tf motifs definition

short, specific nucleotide sequences that act as "addresses" for the TFs.

Example drosophilia homeodomain protein msx1

func

demonstrates a strong affinity for the TAATTA sequence

Example drosophilia homeodomain protein msx1

mech

due to specific amino acid residues in its recognition helix.