carbonyl condensation reactionca

carbonyl condensation rxns what is used as nucleophil and what is used as electrophile and what does it this mechnism do

nucleophile

• enolate

electrophile

• carbonyl carbon

can make carbon-carbon bonds

do ketones or aldehydes work better for aldol reactions

better for aldehydes and not the best for ketones

adol addition reactions happen

with acid base and no heat

adol condensation reactions happens

with acid base and with heat

crossed adol addition

if bothe carbonyl compounds are equally able to form enolate. four possible products 8 possible stereoisomers (cis and trans or E and Z)

cross adol- solution

use carbonyl without alpha hydrogens

use LDA to form 100% enolate

then add the carbonyl intended to be a electrophile slowly

claisen condensation what conditions and product

basic, beta- keto ester

when is the clasiesn reaction reversible

its reversible all teh way till the second deprotonation, of the acidic hydrogen