Papillomaviridae

1907

It is the year papillomavirus is recognized to have a viral etiology

1970’s

Discovered where papillomas in cattle and in other species are caused by different viruses

1935

The year where Peyton Rous observed that benign rabbit papillomas occasionally progressed to carcinomas (early associations of viruses with cancer)

1980s

The year where specific papillomaviruses are a primary cause of cervical and certain other carcinomas in humans

Cutaneous papillomas

This is common in cattle, and less so in other domestic species; Young animals preferentially are affected, and in both dogs and goats there is breed predisposition to development of this

Non-enveloped

Papillomaviridae is enveloped or non-enveloped?

Spherical

Papillomaviridae virons are ____ (55 nm in diameter)

Double-stranded DNA genome

Papillomaviridae genome consists of a ___ stranded genome (6.8 - 8.4kbp)

Icosahedral symmetry

Papillomaviridae has a/an ____ symmetry with 72 hexavalent capsomeres

susceptible

Papillomaviridae are Highly ___ to environmental factors (detergents, low pH, high temperatures)

basal

The infection starts in actively dividing ___ cells of the stratum germinativum, where the virus is maintained in a latent state.

Early viral gene products induce hyperplasia, leading to increased basal cell division and delayed maturation of cells in the stratum spinosum and stratum granulosum.

Episomal oncogenic DNA

Can still cause cancer but remains separate

Birectional replication

Papillomaviridae does ___ where it copies the circular genome leading to the production of new virions.

Nucleus

During replication of papillomaviridae, Capsid proteins are synthesized, and viral particles are assembled in the ___

Exfoliate

The virus completes its cycle when infected cells ___, releasing virions into the environment, ready to infect new hosts through direct contact or contaminated surfaces.

Bovine papillomavirus

Papillomas (warts) are more common in cattle than other domestic animals;Highest incidence occurs in calves and yearlings.

Bovine papillomavirus Types 1 and 2

What bovine papillomavirus belong to the Deltapapillomavirus genus and cause fibropapillomas in cattle and sarcoids in horses

Bovine papillomavirus Types 3, 4, 6, 9, and 10

What bovine papillomavirus belong to the Xipapillomavirus genus that infect epithelial cells, causing true papillomas

Bovine papillomavirus Types 5 and 8

What bovine papillomavirus belong to the Epsilonpapillomavirus genus that cause both fibropapillomas and true papillomas

fomites

The transmission of bovine papillomavirus likely occurs through __ (e.g., milking equipment, halters, grooming tools, fences) contaminated by affected cattle.

Bovine papillomavirus Types 3, 4, 6, 9, and 10:

This BPV Cause epithelial and cutaneous lesions without fibroblast proliferation; Bracken fern may cause progressive papillomas in the alimentary tract, which can lead to squamous cell carcinomas

Equine papillomavirus

This papillomavirus causes aural plaques and cutaneous papillomas in horses; Non-pruritic and non-painful; Do not spontaneously regress like papillomas; Raised, smooth or hyperkeratotic, depigmented plaques/nodules on the inner surface of the ear pinnae

lips

Equine papillomavirus regress after 1-9 months, and most commonly found around the __ and noses of young horses

Equine sarcoid

Most common skin tumor in horses, mules, and donkeys

Most commonly seen in horses under 4 years of age

Can occur singly or in groups, with a preference for the head, ventral abdomen, and limbs

Malignant

Equine sarcoid are Locally aggressive but not __

Bovine papillomavirus types _ and are present in equine sarcoids

1 and 2

Canine papillomavirus has __ Papillomas, _ genera

16 , 3

This papilloma are caused by CPV-1 and possibly CPV-13 and is most common papillomavirus-induced disease of dogs where warts first develop on lips and can spread

Oral papillomas

Cutaneous Papillomavirus

This most often caused by CPV-2, with involvement by CPV-6; Most common on the feet of young dogs

These are single or, more frequently, multiple dark raised plaques that typically occur on the ventrum.

Most common in pugs, present in other breeds too

Cutaneous Pigmented Papilloma

4 , 3

Feline papillomavirus has __ different Felis catus papillomaviruses (FcaPVs) and has genus of __

It is caused by FcaPV-1; Pale sessile lesions on the ventral surface of the tongue

Feline Oral Viral Papillomas

Cutaneous Viral Plagues and Bowenoid in Situ Carcinomas (BISCS)

This is caused by FcaPV-2; associated with the majority of papillomavirus-induced disease of cats; They are similar but uncommon skin lesions of cats; most commonly affects thick-haired areas on the head, neck, dorsal thorax ventrum, and legs.

are dermal fibroblastic proliferations that occur most often in young cats, on the head, neck, and digits. ; almost invariably seen in cats from rural areas that have contact with cattle

Feline sarcoid

Sylvilagus floridamus papillomavirus type 1

First papillomavirus shown to cause cancer; Also known as Cottontail Rabbit Papillomavirus & Shope Papillomavirus

Oryctolagus cuniculus papillomavirus 1

AKA Rabbit oral papillomavirus; Results in self-resolving papillomas which most frequently appear as gray white, filiform or pedunculated nodules (5 mm in diameter) on the underside of the tongue, and less often, the lips.

Papillomas in wild rodents

The papillomavirus detected in exophytic lesions from a beaver (Castor Canadensis Papillomavirus type 1) is unique in that the virus could be propagated in vitro in rabbit and feline cells.

This causes papillomas in wild common chaffinch, brambling, Eurasian bullfinch

Fringilla (finch) Papillomavirus