Jarisch-Herxheimer Reaction

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Last updated 5:06 PM on 7/21/26
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4 Terms

1
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What is a Jarisch-Herxheimer reaction?

A temporary worsening of symptoms shortly after antibiotic treatment of a spirochete infection.

2
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Which disease is most classically associated with a Jarisch-Herxheimer reaction?

Syphilis (Treponema pallidum).

3
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What causes the Jarisch-Herxheimer reaction?

Rapid death of spirochetes causing release of inflammatory molecules and cytokines.

4
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Direct result of killing large numbers of spirochetes with antibiotics?

Jarisch-Herxheimer reaction.