Antibiotics and Toxins that Inhibit Protein Synthesis

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9 Terms

1
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streptomycin and other aminoglycosides

  1. bacteria

  2. inhibits initiation

  3. affects fMet-tRNA-fMet binding to ribosomes

2
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tetracycline

  1. bacteria

  2. binds 30S

  3. inhibits aminoacyl-tRNA binding

3
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chloramphenicol

  1. bacteria

  2. inhibits peptidyl transferase at 50S

4
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cycloheximide

  1. eukaryotes

  2. inhibits translocation

5
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erythromycin

  1. bacteria

  2. inhibits translocation

  3. binds 50S

6
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puromycin

  1. bacteria and eukaryotes

  2. analog of terminal aminoacyl tRNA

  3. binds A site and forms peptide bond

  4. premature chain termination

7
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diphtheria toxin

  1. eukaryotes

  2. attaches ADP-ribose to EF2

  3. prevents translocation

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alpha-sarcin

  1. eukaryotes

  2. ribonuclease

  3. cleaves phosphodiester bond in 28S

9
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ricin

  1. eukaryotes

  2. cleaves adenine from 28S

  3. prevents binding of elongation factors