Brain and Behavior MOA/category for drugs

Bupropion

Inhibits NE and DA reuptake, Atypical Antidepressant

Mirtazapine

alpha 2 antagonist (increase NE and 5-HT release), Atypical antidepressant

Verenicline

Nicotinic ACh receptor partial agonist, smoking cesation

Methadone

opioid agonist

buprenorphine

partial opioid agonist

naloxone

short acting opioid antagonist

naltrexone

long acting opioid antagonist

Tranylcypromine

MOA inhibitor, typical antidepressant, MOA

phenelzine

MOA inhibitor, typical antidepressant, MOA

Isocarboxazid

MOA inhibitor, typical antidepressant, MOA

selegiline

MOA inhibitor, typical antidepressant, MOA

Amitriptyline

Inhibits 5-ht and Ne reuptake, TCA, antidepressant

headache prevention

imipramine, desipramine, clomipramine

Inhibits 5-ht and Ne reuptake, TCA, antidepressant

doxepin, amoxapine

Inhibits 5-ht and Ne reuptake, TCA, antidepressant`

Venlafaxine/Desvenlafaxine

SNRI, antidepressant

duloxetine

SNRI, antidepressant

milnacipran, levomilnacipran

SNRI, antidepressant

Fluoxetine, paroxetine

SSRI, antidepressant

sertraline

SSRI,antidepressant

escitalopram, citalopram

SSRI, antidepressant

buspirone

Partial 5-HT1A agonist, generalized anxiety, 2nd line

Haloperidol

block dopamine D2 receptor, typical antipsych, high potency

Pimozide

block dopamine D2 receptor, typical antipsych, high potency

TrifluperAZINE, AZINE drugs

block dopamine D2 receptor, typical antipsych

Aripiprazole

D2 partial agonist, atypical antipsych

clozAPINE, APINE

D2 and 5-HT 2A receptor blocker, Atypical antipsychs

Benztropine

anticholinergnic, Extrapyramidal symptoms control

amatadine

NMDA Receptor Antagonism, parkinsons/parkinsonism

Valbenazine/deutrabenazine

Tetrabenazine

selectively inhibiting VMAT2,Tardive dyskinesia

huntingtons

Acamprosate

reduce alcohol craving

disulfiram

abstain from alcohol, stops aldehyde dehydrogenase

caffiene

adenosine receptor antagonist

cocaine

blocks the reuptake of dopamine, serotonin, and norepinephrine

Lysergic acid diethylamide

5-HT 2A receptor agonist

Phencyclidine (PCP)

NMDA receptor antagonist

amphetamines

displaces DA,NE, 5-HT , to increase neurotransmiter release

Dantrolene

Stops release of Ca 2+ from sarcomeres, neuropletic malignant syndrome(antipsych) and malignant hyperthermia

cyproheptadine

5-HT2 antagonists (serotonin antagonist), serotonin syndrome

tramadol

weak opiod agonist, inhibits NE, 5 HT reuptake, chronic pain

morphine, fentanyl,codeine

full opiod agonist, close pre synaptic ca 2+, open post synamptic K+, pain/anesthetic

RoCURonium and CUR in middle

competetive Nm nicotinic receptor antagonist, muscle paralysis (nondepol. nueormuscular block)

Succinylcholine

Nm nicotinic receptor agonist, depolarizing neuromuscular block, muscle paralysis

IsoFLURANE, fluranes

Inhaled anesthetics

ketamine

inhibits NMDA receptors, IV anesthetic

Etomidate

Potentiates GABAa receptor, IV anesthetic

propofol

Potentiates GABAa and Inhibits NMDA receptors, IV anesthetic

Benzocaine, CAINES with 1 i

binds to voltage gated Na+ channels on inner membrane, local anesthetic, ESTERs

Lidocaine, caine two i's

binds to voltage gated Na+ channels on inner membrane, local anesthetic, AMIDES

sumatriptan

5-HT agonist, Triptans, stops migraine and cluster headaches

Chlordiazepoxide

Benzo

Phenytoin

blocks Na+ channels, focal seizure

Carbazepine

blocks Na+ channels, focal seizure, trigeminal neuralgia,bipolar

gabapentinoids

blocks ca2+ channels, focal seizure

ethosuximade

blocks t-type ca2+ channels, absence seizure

valproate

blocks Na+,Ca2+, GABA transaminase, Vast seizure, bipolar

lamotrigine

Blocks Na+, broad seizure all, bipolar

Steven Johnsons

Levetiracetem

blocks synamptic vesicle protein 2 a (SV2A), broad seizure

topiramate

blocks Na+, potentials GABA A receptor, broad seizure

verapamil

prevent cluster headache

Pyridostigmine

-Anticholinesterse - increases ACh

-Used in myasthenia gravis (long acting)

physostigmine

-Anticholinesterse - increases ACh, fixes atropine od, cross BBB